ArticleLaboratory animals2021
Experimental replications in animal trials.
Article in Laboratory animals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- A Novel Approach to the Design and Sample Size Planning of Animal Experiments Based on Effect Estimation.Biometrical journal. Biometrische Zeitschrift · 2026Article
- Animal Research in Otorhinolaryngology: Shifts in Publication and Practice Over Two Time Periods.Turkish archives of otorhinolaryngology · 2026Article
- A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research.Scientific reports · 2025Article
- Article
- Comment on Frommlet and Heinze (2021): Correcting the error degrees of freedom.Laboratory animals · 2025Article
- 3D bioprinting for the construction of drug testing models-development strategies and regulatory concerns.Frontiers in bioengineering and biotechnology · 2025Review
- Half the price, twice the gain: How to simultaneously decrease animal numbers and increase precision with good experimental design.Laboratory animals · 2024Article
- Shortwave-Infrared-Emitting Nanoprobes for CD8 Targeting and In Vivo Imaging of Cytotoxic T Cells in Breast Cancer.Advanced nanobiomed research · 2024Article
- Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites.Nature communications · 2023Article
- Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.NMR in biomedicine · 2023Article
- Establishing Institutional Scores With the Rigor and Transparency Index: Large-scale Analysis of Scientific Reporting Quality.Journal of medical Internet research · 2022Article
- Common colonic community indicators of the suckling pig microbiota where diversity and abundance correlate with performance.FEMS microbiology ecology · 2022Article
- Between two stools: preclinical research, reproducibility, and statistical design of experiments.BMC research notes · 2022Article
- Improving reproducibility in animal research.Scientific reports · 2020Article
- The "completely randomised" and the "randomised block" are the only experimental designs suitable for widespread use in pre-clinical research.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent discussion on the reproducibility of scientific results is particularly relevant for preclinical research with animal models. Within certain areas of preclinical research, there exists the tradition of repeating an experiment at least twice to demonstrate replicability. If the results of the first two experiments do not agree, then the experiment might be repeated a third time. Sometimes data of one representative experiment are shown; sometimes data from different experiments are pooled. However, there are hardly any guidelines about how to plan for such an experimental design or how to report the results obtained. This article provides a thorough statistical analysis of pre-planned experimental replications as they are currently often applied in practice and gives some recommendations about how to improve on study design and statistical analysis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.