Evidence map›Paper›PMID 32138583›Full record

ArticleGut microbes2020

The microbiome modulating activity of bile acids.

Yuan Tian, Wei Gui, Imhoi Koo, Philip B Smith, Erik L Allman, Robert G Nichols, Bipin Rimal, Jingwei Cai, Qing Liu, Andrew D Patterson

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 1 synthesis or guideline pooled it, 237 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  7. Review
  8. Article
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  14. Review
  15. Review
  16. GLP-1 agonists and the gut microbiome: A bidirectional relationship.British journal of clinical pharmacology · 2026
    Review
  17. Article
  18. Review
  19. Bile acid signaling, metabolism, and aging.Liver research (Beijing, China) · 2026
    Review
  20. Review

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Yuan TianDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.ORCID 0000-0001-6174-3359
Wei GuiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.
Imhoi KooDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.ORCID 0000-0002-5816-0627
Philip B SmithHuck Institutes of the Life Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.
Erik L AllmanDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.ORCID 0000-0002-6560-0889
Robert G NicholsDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.
Bipin RimalDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.ORCID 0000-0001-6528-5156
Jingwei CaiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.
Qing LiuDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University , University Park, Pennsylvania, USA.ORCID 0000-0003-2073-0070
Pennsylvania State University · US

Funding

Computation, Bioinformatics, and Statistics (CBIOS) Training ProgramT32GM102057 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHIAROMONTE, FRANCESCA, GIRIRAJAN, SANTHOSH · 2013 to 2022
$2.7M
R01: FXR and the Gut Microbiome as Modulators of Non-Alcoholic Fatty Liver DiseaseU01DK119702 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2019 to 2023
$1.5M
Acquisition of an Orbitrap Fusion Lumos Tribid Mass Spectrometer to Accelerate Metabolite Identification and Pathway AnalysisS10OD021750 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2017
$966k
NIDDK NIH HHS U01 DK119702NIGMS NIH HHS T32 GM102057NIH HHS S10 OD021750
6 · The paper itself

Abstract

Bile acids are potent antibacterial compounds and play an important role in shaping the microbial ecology of the gut. Here, we combined flow cytometry, growth rate measurements (OD

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBile Acids and SaltsCecumGlycolysisMaleMetabolomicsMiceMice, Inbred C57BLMicrobial Sensitivity TestsProbioticsBile Acids and SaltsBile acidbile acid resistanceflow cytometrygrowth rate measurementsgut bacteriamass spectrometrymetabolomicsnmr

Identifiers

PMID32138583
PMCPMC7524280
OpenAlexW3009886110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.