Evidence map›Paper›PMID 32138452›Full record

ArticleEndocrine pathology1994

Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretoneurin in primary non-small-cell carcinomas of the lung.

Martin Tötsch, Birgit Kunk, Barbara Dockhorn-Dworniczak, Dietmar Öfner, Reiner Fischer-Colbrie, Gregor Mikuz, Werner Böcker, Kurt Werner Schmid

Abstract read
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Article in Endocrine pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Martin TötschDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
Birgit KunkDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
Barbara Dockhorn-DworniczakDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
Dietmar ÖfnerDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
Reiner Fischer-ColbrieDepartment of Pharmacology, University of Innsbruck, Austria.
Gregor MikuzDepartment of Pathology, University of Innsbruck, Austria.
Werner BöckerDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
Kurt Werner SchmidDepartment of Pathology, University of Münster, Domagkstrasse 17, D-48149, Münster, Germany.
University of Münster · DEUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fifty-three primary non-small-cell lung carcinomas (NSCLC) were immunohistochemically investigated with antibodies against chromogranin A, chromogranin B, and ecretoneurin. All 3 peptides were focally immunolocalized in 3 of 25 adenocarcinomas and in 2 of 6 large-cell anaplastic carcinomas in more than 20% of tumor cells. Two of 15 squamous-cell carcinomas showed chromogranin B reactivity in more than 20% of tumor cells. Neuroendocrine (NE) differentiation was also demonstrated in lymphnode metastases of large-cell anaplastic carcinomas, in 1 adenocarcinoma, and in 1 squamous-cell carcinoma, with NE differentiation of the respective primary tumors. All tumors with NE differentiation exhibited (large cell) anaplastic tumor areas. We conclude that NE differentiation should be immunohistochemically proven or excluded, particularly in NSCLC with anaplastic components. Chromogranin B and secretoneurin are proposed as useful additional neuroendocrine markers for demonstration of NE differentiation in lung carcinomas.

Indexed as

Bronchial CarcinoidEndocrine Pathology VolumeImmunohistochemical DemonstrationLung CarcinoParagangliomas

Identifiers

PMID32138452
OpenAlexW1970790549

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.