ArticleInternational journal of molecular sciences2020
Transcriptome Analysis Reveals Long Intergenic Non-Coding RNAs Contributed to Intramuscular Fat Content Differences between Yorkshire and Wei Pigs.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 33 citations in OpenAlex.
- Identification and Functional Validation ofGenes · 2025Article
- Identification of Key Genes Related to Intramuscular Fat Content of Psoas Major Muscle in Saba Pigs by Integrating Bioinformatics and Machine Learning Based on Transcriptome Data.Animals : an open access journal from MDPI · 2025Article
- Association of weight-adjusted-waist index with all-cause and cardiovascular mortality in individuals with diabetes or prediabetes: a cohort study from NHANES 2005-2018.Scientific reports · 2024Article
- Identification of key genes affecting intramuscular fat deposition in pigs using machine learning models.Frontiers in genetics · 2024Article
- Comparative muscle transcriptome of Mali and Hampshire breeds of pigs: a preliminary study.Animal biotechnology · 2023Article
- Comparison of Growth Performance and Plasma Metabolomics between Two Sire-Breeds of Pigs in China.Genes · 2023Article
- Lipo-nutritional quality of pork: The lipid composition, regulation, and molecular mechanisms of fatty acid deposition.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Article
- Integrated Analysis of Long Non-Coding RNA and mRNA to Reveal Putative Candidate Genes Associated with Backfat Quality in Beijing Black Pig.Foods (Basel, Switzerland) · 2022Article
- Identification of Candidate Genes and Regulatory Competitive Endogenous RNA (ceRNA) Networks Underlying Intramuscular Fat Content in Yorkshire Pigs with Extreme Fat Deposition Phenotypes.International journal of molecular sciences · 2022Article
- Copy Number Variations Contribute to Intramuscular Fat Content Differences by Affecting the Expression ofAnimals : an open access journal from MDPI · 2022Article
- Genome-wide detection of genetic structure and runs of homozygosity analysis in Anhui indigenous and Western commercial pig breeds using PorcineSNP80k data.BMC genomics · 2022Article
- Article
- Integration of ATAC-seq and RNA-seq analysis identifies key genes affecting intramuscular fat content in pigs.Frontiers in nutrition · 2022Article
- Comparative analysis of differentially abundant proteins between high and low intramuscular fat content groups in donkeys.Frontiers in veterinary science · 2022Article
- Genome-wide characterization of lncRNAs and mRNAs in muscles with differential intramuscular fat contents.Frontiers in veterinary science · 2022Article
- Systematic Identification and Comparison of the Expressed Profiles of lncRNAs, miRNAs, circRNAs, and mRNAs with Associated Co-Expression Networks in Pigs with Low and High Intramuscular Fat.Animals : an open access journal from MDPI · 2021Article
- How Does Protein Nutrition Affect the Epigenetic Changes in Pig? A Review.Animals : an open access journal from MDPI · 2021Review
- IRLnc: a novel functional noncoding RNA contributes to intramuscular fat deposition.BMC genomics · 2021Article
- Genome-Wide Identification of RNA Editing Sites Affecting Intramuscular Fat in Pigs.Animals : an open access journal from MDPI · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intramuscular fat (IMF) content is closely related to various meat traits, such as tenderness, juiciness, and flavor. The IMF content varies considerably among pig breeds with different genetic backgrounds. Long intergenic non-coding RNAs (lincRNAs) have been widely identified in many species and found to be an important class of regulators that can participate in multiple biological processes. However, the mechanism behind lincRNAs regulation of pig IMF content remains unknown and requires further study. In our study, we identified a total of 156 lincRNAs in the longissimus dorsi muscle of Wei (fat-type) and Yorkshire (lean-type) pigs using previously published data. These identified lincRNAs have shorter transcript length, longer exon length, lower exon number, and lower expression level as compared with protein-coding transcripts. We predicted potential target genes (PTGs) that are potentially regulated by lincRNAs in cis or trans regulation. Gene ontology and pathway analyses indicated that many potential lincRNAs target genes are involved in IMF-related processes or pathways, such as fatty acid catabolic process and adipocytokine signaling pathway. In addition, we analyzed quantitative trait locus (QTL) sites that differentially expressed lincRNAs (DE lincRNAs) between Wei and Yorkshire pigs co-localized. The QTL sites where DE lincRNAs co-localize are mostly related to IMF content. Furthermore, we constructed a co-expressed network between DE lincRNAs and their differentially expressed PTGs (DEPTGs). On the basis of their expression levels, we suggest that many DE lincRNAs can affect IMF development by positively or negatively regulating their PTGs. This study identified and analyzed some lincRNAs- and PTGs-related IMF development of the two pig breeds and provided new insight into research on the roles of lincRNAs in the two types of breeds.
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