ReviewInternational journal of environmental research and public health2020
Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments.
Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Landscape complexity and agricultural pressure at the habitat-level scale determine impact of insecticide use on future generation of non-target arthropods (ground beetle Poecilus cupreus).Ecotoxicology (London, England) · 2026Article
- Neonicotinoids: insecticides or a threat to public health?Frontiers in public health · 2026Article
- Review
- Multiple Stressor Effects of a Neonicotinoid, Heatwaves, and Elevated Temperatures on Aquatic Insect Emergence.Environmental science & technology · 2025Article
- The Temporal Response Surface: A Novel Method for the Assessment of Delayed and Time-Cumulative Aquatic Ecosystem Risk.Environmental science & technology · 2025Article
- Article
- Article
- Selected neonicotinoids and associated risk for aquatic organisms.Veterinarni medicina · 2023Review
- Monitoring resistance to methomyl and synergism in the non-target Musca domestica from cotton fields of Punjab and Sindh provinces, Pakistan.Scientific reports · 2023Article
- Pesticides in ambient air, influenced by surrounding land use and weather, pose a potential threat to biodiversity and humans.The Science of the total environment · 2022Article
- Long-Term Effects of Imidacloprid, Thiacloprid, and Clothianidin on the Growth and Development of Eisenia andrei.Environmental toxicology and chemistry · 2022Article
- Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals-An Updated Review.International journal of molecular sciences · 2021Review
- Long-term field-realistic exposure to a next-generation pesticide, flupyradifurone, impairs honey bee behaviour and survival.Communications biology · 2021Article
- Similarities between pandemics and cancer in growth and risk models.Scientific reports · 2021Article
- The novel insecticides flupyradifurone and sulfoxaflor do not act synergistically with viral pathogens in reducing honey bee (Apis mellifera) survival but sulfoxaflor modulates host immunocompetence.Microbial biotechnology · 2021Article
- Evaluation of Systemic Imidacloprid and Herbicide Treatments on Flatheaded Borer (Coleoptera: Buprestidae) Management in Field Nursery Production.Journal of economic entomology · 2020Article
- Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor.International journal of environmental research and public health · 2020Article
- Long-term effects of neonicotinoid insecticides on ants.Communications biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our mechanistic understanding of the toxicity of chemicals that target biochemical and/or physiological pathways, such as pesticides and medical drugs is that they do so by binding to specific molecules. The nature of the latter molecules (e.g., enzymes, receptors, DNA, proteins, etc.) and the strength of the binding to such chemicals elicit a toxic effect in organisms, which magnitude depends on the doses exposed in a given timeframe. While dose and time of exposure are critical factors determining the toxicity of pesticides, different types of chemicals behave differently. Experimental evidence demonstrates that the toxicity of neonicotinoids increases with exposure time as much as with the dose, and therefore it has been described as time-cumulative toxicity. Examples for aquatic and terrestrial organisms are shown here. This pattern of toxicity, also found among carcinogenic compounds and other toxicants, has been ignored in ecotoxicology and risk assessments for a long time. The implications of the time-cumulative toxicity of neonicotinoids on non-target organisms of aquatic and terrestrial environments are far reaching. Firstly, neonicotinoids are incompatible with integrated pest management (IPM) approaches and secondly regulatory assessments for this class of compounds cannot be based solely on exposure doses but need also to take into consideration the time factor.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.