Evidence map›Paper›PMID 32138262›Full record

ArticleTropical medicine and infectious disease2020

Strain-Dependent Activity of Zika Virus and Exposure History in Serological Diagnostics.

Kelli L Barr, Erika R Schwarz, Dhani Prakoso, Kehkashan Imtiaz, Ruiyu Pu, J Glenn Morris Jr, Erum Khan, Maureen T Long

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kelli L BarrDepartment of Biology, Baylor University, Waco, TX 76798, USA.ORCID 0000-0001-7943-7181
Erika R SchwarzDepartment of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Dhani PrakosoDepartment of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
Kehkashan ImtiazDepartment of Pathology and Laboratory Medicine, Aga Khan University, Karachi 74800, Pakistan.
Ruiyu PuDepartment of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
J Glenn Morris JrEmerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA.ORCID 0000-0001-9347-1984
Erum KhanDepartment of Pathology and Laboratory Medicine, Aga Khan University, Karachi 74800, Pakistan.
Maureen T LongDepartment of Comparative Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.ORCID 0000-0001-5337-9024
University of Florida · USAga Khan University · PKBaylor University · US

Funding

Defense Threat Reduction Agency HDRTA1-14-1-0022Florida Department of Health 7ZK12Horizon 2020 734857
6 · The paper itself

Abstract

Zika virus (ZIKV) circulates as two separate lineages, with significant genetic variability between strains. Strain-dependent activity has been reported for dengue virus, herpes simplex virus and influenza. Strain-dependent activity of subject specimens to a virus could be an impediment to serological diagnosis and vaccine development. In order to determine whether ZIKV exhibits strain-dependent activity when exposed to antibodies, we measured the neutralizing properties of polyclonal serum and three monoclonal antibodies (ZKA185, 753(3)C10, and 4G2) against three strains of ZIKV (MR-766, PRVABC59, and R103454). Here, MR-766 was inhibited almost 60% less by ZKA185 than PRVABC59 and R103454 (

Indexed as

cross-reactivitydiagnosticsflavivirusflavivirus exposureneutralizationplaque reduction neutralization testserologyZika virus

Identifiers

PMID32138262
PMCPMC7157670
OpenAlexW3010599516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.