Evidence map›Paper›PMID 32138228›Full record

ArticleProteomes2020

Proteomics-Based Detection of Immune Dysfunction in an Elite Adventure Athlete Trekking Across the Antarctica.

David C Nieman, Arnoud J Groen, Artyom Pugachev, Andrew J Simonson, Kristine Polley, Karma James, Bassem F El-Khodor, Saradhadevi Varadharaj, Claudia Hernández-Armenta

Open access · goldAbstract read
In one paragraph

Article in Proteomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David C NiemanNorth Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA.ORCID 0000-0002-8305-1860
Arnoud J GroenProteiQ Biosciences GmbH, 10967 Berlin, Germany.
Artyom PugachevProteiQ Biosciences GmbH, 10967 Berlin, Germany.
Andrew J SimonsonNorth Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA.
Kristine PolleyStandard Process Nutrition Innovation, Kannapolis, NC 28081, USA.
Karma JamesStandard Process Nutrition Innovation, Kannapolis, NC 28081, USA.
Bassem F El-KhodorStandard Process Nutrition Innovation, Kannapolis, NC 28081, USA.
Saradhadevi VaradharajStandard Process Nutrition Innovation, Kannapolis, NC 28081, USA.
Claudia Hernández-ArmentaProteiQ Biosciences GmbH, 10967 Berlin, Germany.
Appalachian State University · US

Funding

Standard Process Inc. 18-0238
6 · The paper itself

Abstract

Proteomics monitoring of an elite adventure athlete (age 33 years) was conducted over a 28-week period that culminated in the successful, solo, unassisted, and unsupported two month trek across the Antarctica (1500 km). Training distress was monitored weekly using a 19-item, validated training distress scale (TDS). Weekly dried blood spot (DBS) specimens were collected via fingerprick blood drops onto standard blood spot cards. DBS proteins were measured with nano-electrospray ionization liquid chromatography tandem mass spectrometry (nanoLC-MS/MS) in data-independent acquisition (DIA) mode, and 712 proteins were identified and quantified. The 28-week period was divided into time segments based on TDS scores, and a contrast analysis between weeks five and eight (low TDS) and between weeks 20 and 23 (high TDS, last month of Antarctica trek) showed that 31 proteins (

Indexed as

apolipoproteinsblood proteinscomplementexerciseimmune systemneutrophilsnutrition

Identifiers

PMID32138228
PMCPMC7151708
OpenAlexW3009193868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.