Evidence map›Paper›PMID 32138218›Full record

ArticleInternational journal of molecular sciences2020

Role of the TRPC1 Channel in Hippocampal Long-Term Depression and in Spatial Memory Extinction.

Xavier Yerna, Olivier Schakman, Ikram Ratbi, Anna Kreis, Sophie Lepannetier, Marie de Clippele, Younès Achouri, Nicolas Tajeddine, Fadel Tissir, Roberta Gualdani and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced CaThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. How TRPC Channels Modulate Hippocampal Function.International journal of molecular sciences · 2020
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xavier YernaUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Olivier SchakmanUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Ikram RatbiUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Anna KreisUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Sophie LepannetierUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Marie de ClippeleUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Younès AchouriUniversité Catholique de Louvain, de Duve Institute, Transgenic Core Facility, av. Hippocrate 75/B1.75.09, B-1200 Brussels, Belgium.
Nicolas TajeddineUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.
Fadel TissirUniversité Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology, av. Mounier 73/B1.73.16, B-1200 Brussels, Belgium.ORCID 0000-0002-9292-6622
Roberta GualdaniUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.ORCID 0000-0003-3617-4953
Philippe GaillyUniversité Catholique de Louvain, Institute of Neuroscience, Cell Physiology, av. Mounier 53/B1.53.17, B-1200 Brussels, Belgium.ORCID 0000-0002-9259-3813
UCLouvain · BEde Duve Institute · BE

Funding

Concerted Research Action from the General Direction of Scientific Research of the French Community of Belgium ARC17/22-083Fondation pour la Recherche sur la Maladie d'Alzheimer (SAO/FRA) -Fonds De La Recherche Scientifique - FNRS EQP U.N011.17Queen Elisabeth Medical Foundation -
6 · The paper itself

Abstract

Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that are believed to underlie declarative memory. We previously showed that mGluR5 specifically activates channels containing TRPC1, an isoform of the canonical family of Transient Receptor Potential channels highly expressed in the CA1-3 regions of the hippocampus. Using a tamoxifen-inducible conditional knockout model, we show here that the acute deletion of the

Indexed as

AnimalsDepressionHippocampusMaleMAP Kinase Signaling SystemMiceMice, KnockoutNeuronal PlasticityReceptors, AMPAReceptors, Metabotropic GlutamateSignal TransductionSpatial MemoryTRPC Cation ChannelsReceptors, AMPAReceptors, Metabotropic Glutamatetransient receptor potential cation channel, subfamily C, member 1TRPC Cation Channelslong-term depressionmemory extinctionmGluRTRPC

Identifiers

PMID32138218
PMCPMC7084652
OpenAlexW3009365194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.