Evidence map›Paper›PMID 32135475›Full record

ArticleNuclear medicine and biology

Fluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitor as a potential alternative to 2-deoxy-2-[

Paula Demétrio de Souza França, Sheryl Roberts, Susanne Kossatz, Navjot Guru, Christian Mason, Daniella Karassawa Zanoni, Marcio Abrahão, Heiko Schöder, Ian Ganly, Snehal G Patel and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Novel Tracers and Radionuclides in PET Imaging.Radiologic clinics of North America · 2021
    Review
  8. PARP1: A Potential Molecular Marker to Identify Cancer During Colposcopy Procedures.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  9. [Molecular imaging · 2021
    Article
  10. Article
  11. Review
  12. A one-pot radiosynthesis of [Journal of labelled compounds & radiopharmaceuticals · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Paula Demétrio de Souza FrançaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Otorhinolaryngology and Head and Neck Surgery, Federal University of São Paulo, SP, Brazil. Electronic address: demetrip@mskcc.org.
Sheryl RobertsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: roberts3@mskcc.org.
Susanne KossatzDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: s.kossatz@tum.de.
Navjot GuruDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: gurun@mskcc.org.
Christian MasonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: masonc@mskcc.org.
Daniella Karassawa ZanoniDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marcio AbrahãoDepartment of Otorhinolaryngology and Head and Neck Surgery, Federal University of São Paulo, SP, Brazil.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: schoderh@mskcc.org.
Ian GanlyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address: ganlyi@mskcc.org.
Snehal G PatelDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address: patels@mskcc.org.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: reinert@mskcc.org.
Memorial Sloan Kettering Cancer Center · USCornell University · USUniversidade Federal de São Paulo · BR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
Rapid, quantitative and affordable point-of-care diagnostics for oral and oropharyngeal cancerR43CA228815 · NCI · SUMMIT BIOMEDICAL IMAGING, LLC · PI BRAND, CHRISTIAN, REINER, THOMAS · 2018 to 2018
$300k
Evaluation of PARP1 targeted imaging as screening tool for esophageal adenocarcinomaK99CA218875 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KOSSATZ, SUSANNE · 2018 to 2018
$106k
NCI NIH HHS K99 CA218875NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441NCI NIH HHS R43 CA228815
6 · The paper itself

Abstract

objectivesThe evaluation of disease extent and post-therapy surveillance of head and neck cancer using 2-deoxy-2-[

methodsUsing an orthotopic xenograft mouse model injected with either FaDu or Cal 27 (human squamous cell carcinoma cell lines) we performed PET/CT scans with the 2 tracers and compared the results. Gamma counts and autoradiography were also assessed and correlated with histology.

resultsThe average retained activity of [ CONCLUSIONS AND IMPLICATIONS FOR PATIENT CARE: We demonstrate that [

Indexed as

Fluorodeoxyglucose F18AnimalsCell Line, TumorCell Transformation, NeoplasticEnzyme InhibitorsFluorine RadioisotopesHumansIsotope LabelingMiceMouth NeoplasmsPoly (ADP-Ribose) Polymerase-1Positron-Emission TomographyRadiochemistrySignal-To-Noise RatioEnzyme InhibitorsFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18Poly (ADP-Ribose) Polymerase-1[(18)F]FDG[(18)F]PARPi2-deoxy-2-[(18)F]fluoro-d-glucoseFluorine-18 labeled poly (ADP-ribose) polymerase1 inhibitorOral cancerPET/CTSquamous cell carcinoma

Identifiers

PMID32135475
PMCPMC7253343
OpenAlexW3001747403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.