ArticleAmerican journal of respiratory cell and molecular biology2020
Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats.
Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Early dysanapsis in experimental bronchopulmonary dysplasia: implications for lifelong lung disease.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Development of late pulmonary hypertension after antenatal inflammation in experimental bronchopulmonary dysplasia.Pediatric research · 2026Article
- Developing a prediction model of neonatal pneumonia in patients with gestational diabetes mellitus in primary medical institutions.Frontiers in pediatrics · 2026Article
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Vitamin D: What We Know and What We Still Do Not Know About Vitamin D in Preterm Infants-A Literature Review.Children (Basel, Switzerland) · 2025Review
- Specific airway resistance according to early maternal vitamin D status during pregnancy in children aged 5 to 6 years old from the FEPED cohort (RESPIFEPED).European journal of pediatrics · 2025Article
- Pharmacokinetic modeling of prenatal vitamin D exposure and the impact on offspring asthma and pulmonary function.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Article
- Impact of vitamin D on hyperoxic acute lung injury in neonatal mice.BMC pulmonary medicine · 2024Article
- Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia.American journal of respiratory cell and molecular biology · 2024Article
- Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?Nutrients · 2023Article
- Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during postnatal growth.iScience · 2023Article
- Impact of vitamin D on maternal and fetal health: A review.Food science & nutrition · 2022Review
- HLA-A2 Promotes the Therapeutic Effect of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Hyperoxic Lung Injury.Bioengineering (Basel, Switzerland) · 2022Article
- Contributing factors common to COVID‑19 and gastrointestinal cancer.Oncology reports · 2022Review
- Current Overview on Therapeutic Potential of Vitamin D in Inflammatory Lung Diseases.Biomedicines · 2021Review
- Vitamin D Endocrine System and COVID-19.JBMR plus · 2021Article
- Vitamin D Deficiency in Development: How Much Is Enough, and How Much Is Too Much?American journal of respiratory cell and molecular biology · 2021Article
- Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021Article
- Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children.The Journal of allergy and clinical immunology · 2021Article
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7 authors at 4 institutions in 1 country.
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Abstract
Vitamin D deficiency (VDD) during pregnancy is associated with increased respiratory morbidities and risk for chronic lung disease after preterm birth. However, the direct effects of maternal VDD on perinatal lung structure and function and whether maternal VDD increases the susceptibility of lung injury due to hyperoxia are uncertain. In the present study, we sought to determine whether maternal VDD is sufficient to impair lung structure and function and whether VDD increases the impact of hyperoxia on the developing rat lung. Four-week-old rats were fed VDD chow and housed in a room shielded from ultraviolet A/B light to achieve 25-hydroxyvitamin D concentrations <10 ng/ml at mating and throughout lactation. Lung structure was assessed at 2 weeks for radial alveolar count, mean linear intercept, pulmonary vessel density, and lung function (lung compliance and resistance). The effects of hyperoxia for 2 weeks after birth were assessed after exposure to fraction of inspired oxygen of 0.95. At 2 weeks, VDD offspring had decreased alveolar and vascular growth and abnormal airway reactivity and lung function. Impaired lung structure and function in VDD offspring were similar to those observed in control rats exposed to postnatal hyperoxia alone. Maternal VDD causes sustained abnormalities of distal lung growth, increases in airway hyperreactivity, and abnormal lung mechanics during infancy. These changes in VDD pups were as severe as those measured after exposure to postnatal hyperoxia alone. We speculate that antenatal disruption of vitamin D signaling increases the risk for late-childhood respiratory disease.
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