Evidence map›Paper›PMID 32134488›Full record

ReviewThe Journal of infectious diseases2020

Clinical Diagnostic Testing for Human Cytomegalovirus Infections.

Raymund R Razonable, Naoki Inoue, Swetha G Pinninti, Suresh B Boppana, Tiziana Lazzarotto, Liliana Gabrielli, Giuliana Simonazzi, Philip E Pellett, D Scott Schmid

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Raymund R RazonableDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Naoki InoueGifu Pharmaceutical University, Gifu, Japan.
Swetha G PinnintiDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Suresh B BoppanaDepartment of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tiziana LazzarottoOperative Unit of Microbiology and Virology, Department of Specialized, Experimental, and Diagnostic Medicine, Polyclinic of St Orsola-Malpighi, University of Bologna, Italy.
Liliana GabrielliOperative Unit of Microbiology and Virology, Department of Specialized, Experimental, and Diagnostic Medicine, Polyclinic of St Orsola-Malpighi, University of Bologna, Italy.
Giuliana SimonazziOperative Unit of Obstetrics and Prenatal Medicine, Department of Medical Surgical Sciences, Polyclinic of St Orsola-Malpighi, University of Bologna, Italy.
Philip E PellettDepartment of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, Michigan, USA.
D Scott SchmidViral Vaccine Preventable Diseases Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
University of Alabama at Birmingham · USUniversity of Bologna · ITCenters for Disease Control and Prevention · USGifu Pharmaceutical University · JPMayo Clinic · USPoliclinico S.Orsola-Malpighi · ITWayne State University · US

Funding

NIDCD NIH HHS HHSN263201200010CNIDCD NIH HHS N01 DC050008NIDCD NIH HHS N01 DC50008-6-0-1
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States.

Indexed as

CytomegalovirusDiagnostic Tests, RoutineAlgorithmsClinical Decision-MakingCytomegalovirus InfectionsDisease ManagementFemaleHost-Pathogen InteractionsHumansInfant, NewbornInfectious Disease Transmission, VerticalMolecular Diagnostic TechniquesNeonatal ScreeningOrgan TransplantationPregnancyPregnancy Complications, Infectiouscongenital infectiondiagnosishuman cytomegaloviruspregnancy

Identifiers

PMID32134488
PMCPMC7057790
OpenAlexW3009566353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.