Evidence map›Paper›PMID 32134140›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020

Platelet-derived growth factor receptor-β (PDGFRβ) lineage tracing highlights perivascular cell to myofibroblast transdifferentiation during post-traumatic osteoarthritis.

Takashi Sono, Ching-Yun Hsu, Stefano Negri, Sarah Miller, Yiyun Wang, Jiajia Xu, Carolyn A Meyers, Bruno Peault, Aaron W James

Open access · greenAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  3. Article
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  5. Article
  6. Article
  7. Blood Vessel Resident Human Stem Cells in Health and Disease.Stem cells translational medicine · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Takashi SonoDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0001-5599-0185
Ching-Yun HsuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Stefano NegriDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Sarah MillerDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Yiyun WangDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Jiajia XuDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Carolyn A MeyersDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Bruno PeaultDepartment of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, UCLA and Orthopaedic Hospital, Los Angeles, California.
Aaron W JamesDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USMRC Centre for Regenerative Medicine · GB

Funding

Direct and indirect contributions of perivascular stem cells to bone healingR01AR070773 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI JAMES, AARON W · 2017 to 2021
$1.4M
NELL-1 isoforms for the systemic treatment of osteoporosisK08AR068316 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES, AARON W · 2015 to 2019
$534k
Role of sensory nerves in cranial bone repairR21DE027922 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI CLEMENS, THOMAS L, JAMES, AARON W · 2018 to 2019
$450k
Medical Research Council G1000816Medical Research Council MR/K017047/1NIAMS NIH HHS K08 AR068316NIAMS NIH HHS R01 AR070773NIDCR NIH HHS R21 DE027922
6 · The paper itself

Abstract

Pericytes ubiquitously surround capillaries and microvessels within vascularized tissues and have diverse functions after tissue injury. In addition to regulation of angiogenesis and tissue regeneration after injury, pericytes also contribute to organ fibrosis. Destabilization of the medial meniscus (DMM) phenocopies post-traumatic osteoarthritis, yet little is known regarding the impact of DMM surgery on knee joint-associated pericytes and their cellular descendants. Here, inducible platelet-derived growth factor receptor-β (PDGFRβ)-CreER

Indexed as

Cell TransdifferentiationAnimalsArthritis, ExperimentalCell LineageFemaleFibrosisGenes, ReporterJointsMaleMiceMice, TransgenicMyofibroblastsOsteoarthritisPericytesReceptor, Platelet-Derived Growth Factor betaReceptor, Platelet-Derived Growth Factor betaDMMmyofibroblastPDGFRβpericyteperivascular stem cell

Identifiers

PMID32134140
PMCPMC7483913
OpenAlexW3009414875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.