ArticleObesity (Silver Spring, Md.)2020
Weight Loss After Obesity is Associated with Increased Food Motivation and Faster Weight Regain in Mice.
Article in Obesity (Silver Spring, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Revisiting food addiction in the era of GLP-1-based obesity pharmacotherapy via neural reward pathways linking feeding and substance use.Frontiers in behavioral neuroscience · 2026Review
- Weight Loss After Obesity Disrupts Cognitive Flexibility Through Reinforcement Learning Strategies.Obesity (Silver Spring, Md.) · 2026Article
- A simple action reduces high-fat diet intake and obesity in mice.Current biology : CB · 2025Article
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- Isocaloric high-fat diet decreases motivation in the absence of obesity.Obesity (Silver Spring, Md.) · 2025Article
- The potential effect of α7 nicotinic receptors modulation on palatable food-induced dependence-like behaviors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- AMPK in the gut-liver-brain axis and its influence on OP rats in an HSHF intake and WTD rat model.Pflugers Archiv : European journal of physiology · 2021Article
- An open-source device for measuring food intake and operant behavior in rodent home-cages.eLife · 2021Article
- Physiological Responses of Post-Dietary Effects: Lessons from Pre-Clinical and Clinical Studies.Metabolites · 2021Review
- The Impact of Maternal High-Fat Diet on Bone Microarchitecture in Offspring.Frontiers in nutrition · 2021Review
- A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding.Nature communications · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWhile changes in diet often result in short-term weight loss, weight loss is not typically maintained. It remains unclear why long-term weight loss is so difficult. It was hypothesized that obesity produces persistent changes in behavior that bias animals toward weight regain after weight loss.
methodsMice were induced to gain weight with a high-fat diet for 6 weeks and then induced to lose this weight with a low-fat diet for 7 subsequent weeks. A control group was maintained on the low-fat diet for all 13 weeks. Activity was measured continuously with home cage activity monitors for the entire experiment. Motivation for sweetened food pellets was tested following weight loss. A separate group of mice was reexposed to a high-fat diet following 2, 4, or 8 weeks of withdrawal to assess the rate of weight regain.
resultsActivity levels decreased as animals gained weight and partially recovered following weight loss. Motivation for sucrose pellets was persistently heightened after weight loss. Consistent with these behavioral changes, mice also regained weight at a faster rate when reexposed to a high-fat diet after a period of weight loss.
conclusionsWeight loss after obesity was associated with increased motivation for palatable food and an increased rate of weight regain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.