ArticleJournal of clinical laboratory analysis2020
A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Elevated AKIP1 expression is associated with tumor invasion, shorter survival time and decreased chemosensitivity in endometrial carcinoma.Oncology letters · 2022Article
- Cell-Penetrating Peptides Predicted From CASC3, AKIP1, and AHRR Proteins.Frontiers in pharmacology · 2021Article
- AKIP1 promotes tumor progression by cancer-related pathways and predicts prognosis in tongue squamous cell carcinoma.American journal of translational research · 2021Article
- A-Kinase Interacting Protein 1 Promotes Cell Invasion and StemnessFrontiers in oncology · 2021Article
- A-kinase interacting protein 1 as a potential biomarker of advanced tumor features and increased recurrence risk in papillary thyroid carcinoma patients.Journal of clinical laboratory analysis · 2020Article
- A-kinase interacting protein 1 (AKIP1) associates with advanced overall disease condition, tumor properties, and unfavorable prognosis in hepatocellular carcinoma patients.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe presented study aimed to investigate the association of A-kinase interacting protein 1 (AKIP1) expression with tumor properties, liver functions, cancer markers, and overall survival (OS) of hepatocellular carcinoma (HCC) patients.
methodsA total of 432 HCC patients receiving surgery were retrospectively reviewed in our study. Clinical characteristics of patients were obtained. Tumor tissue specimens of all patients were collected, and AKIP1 expression was evaluated by immunohistochemistry (IHC) assay. OS was assessed, and the median follow-up duration was 35.0 months. AKIP1 high expression was defined as total IHC score more than 3 and was further graded as AKIP1 high+ (IHC 4-6), AKIP1 high++ (IHC 7-9), and AKIP1 high+++ (IHC 10-12).
resultsAbout 265 (61.3%) patients presented with AKIP1 low expression and 167 (38.7%) patients had AKIP1 high expression. AKIP1 high expression correlated with higher performance status score (P = .006), largest tumor size ≥5.0 cm (P < .001), Barcelona clinic liver cancer (BCLC) stage B (vs stage A; P = .024), increased alpha-fetoprotein level (P = .036), and higher carbohydrate antigen 199 level (P < .001). AKIP1 high expression (P < .001) and increased AKIP1 expression grade (P < .001) both correlated with worse OS, and Cox's regression analyses revealed that AKIP1 high expression (P < .001) was an independent predictive factor for shorter OS. In subgroup analysis, AKIP1 high expression and more advanced AKIP1 expression grade associated with worse OS in both BCLC stage A subgroup patients (both P < .001) and BCLC stage B subgroup patients (both P < .001), respectively.
conclusionAKIP1 is a novel and promising biomarker for disease monitoring and prognosis in HCC patients.
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