Evidence map›Paper›PMID 32133670›Full record

ArticleAlimentary pharmacology & therapeutics2020

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions.

Boldbaatar Gantuya, Hashem B El Serag, Takashi Matsumoto, Nadim J Ajami, Tomohisa Uchida, Khasag Oyuntsetseg, Dashdorj Bolor, Yoshio Yamaoka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 3 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

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  4. Pronounced ethnic and sex disparities in gastric cancer burden and healthcare utilization in Inner Mongolia: a 9-year population-based cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Boldbaatar GantuyaDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.ORCID 0000-0003-4293-0532
Hashem B El SeragDepartment of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5964-7579
Takashi MatsumotoDepartment of Environmental and Preventive Medicine, Oita University of Medicine, Yufu, Japan.
Nadim J AjamiDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Tomohisa UchidaDepartment of Molecular Pathology, Oita University of Medicine, Yufu, Japan.
Khasag OyuntsetsegDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Dashdorj BolorDepartment of Endoscopy, Mongolian National Cancer Center Hospital, Ulaanbaatar, Mongolia.
Yoshio YamaokaDepartment of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1222-5819
Baylor College of Medicine · USMongolian National University · MNOita University · JPNational Center for Communicable Diseases · MN

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIR01DK062813 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI YAMAOKA, YOSHIO · 2004 to 2013
$3.0M
NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK062813
6 · The paper itself

Abstract

backgroundIncidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent.

aimTo evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions.

methodsWe conducted a case-control study among 48 GC and 120 noncancer patients (20 normal gastric mucosa [control], 20 gastritis, 40 with atrophy and 40 intestinal metaplasia [IM]). We performed 16S rRNA gene amplicon sequencing and compared taxonomic and functional prediction profiles based on the diagnosis group and H pylori infection status.

resultsThe highest overall bacterial alpha diversity metrics were observed in the control group, followed by the IM and cancer groups. The gastritis and atrophy groups had the least diversity. Lactobacilli and Enterococci were the dominant genus in several cancer patients especially in the absence of H pylori. In addition, Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium and Parvimonas were associated with GC regardless of H pylori infection. Firmicutes were decreased in the gastritis and atrophy groups and increased in the IM and cancer groups. The functional metabolic activity of the Embden-Meyerhof-Parnas pathway and the utilization of sugar, were significantly increased in cancer group compared with the noncancer group.

conclusionMicrobial factors other than H pylori may play a role in Mongolian GC. We identified novel associations between GC and the genera Enterococcus, Lactobacillus, Carnobacterium, Glutamicibacter, Paeniglutamicibacter, Fusobacterium, and Parvimonas.

Indexed as

Gastrointestinal MicrobiomeAdultAgedAsian PeopleCase-Control StudiesCross-Sectional StudiesFemaleGastric MucosaGastritisHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMetaplasiaMiddle AgedRNA, Ribosomal, 16S

Identifiers

PMID32133670
PMCPMC8761497
OpenAlexW3009896646

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.