Observational studyAge and ageing2020
Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality.
Observational study in Age and ageing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Hypertension in Adults With Diabetes in Southeast Asia: A Systematic Review.Journal of clinical hypertension (Greenwich, Conn.) · 2025Pooled it
- Changes in frailty, intensive blood pressure treatment, and risks of adverse clinical outcomes: a post hoc analysis of the SPRINT trial.BMC medicine · 2025Trial
- Cardiovascular frailty - an emerging frailty phenotype.Journal of human hypertension · 2026Review
- Consensus statement on practical guidance for optimizing antihypertensive therapy in older adults needing nursing care by the Japan Geriatrics Society and the Japanese Society of Hypertension: English translation of the Japanese article.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Effects of a 6-Month Educational Program on Blood Pressure in Pre-Frail and Frail Older Adults: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Consensus Statement on Practical Guidance for Optimizing Antihypertensive Therapy in Older Adults Needing Nursing Care by the Japan Geriatrics Society and the Japanese Society of Hypertension: English Translation of the Japanese Article.Geriatrics & gerontology international · 2026Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Blood pressure and adverse cardiovascular outcomes in older people with type 2 diabetes and chronic kidney disease: Findings based on the Clinical Practice Research Datalink databases in England.Diabetes, obesity & metabolism · 2026Article
- Practitioners' views on the measurement and management of postural hypotension in general practice: a qualitative inquiry.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Frailty and stroke: Global implications for assessment, research, and clinical care-A WSO scientific statement.International journal of stroke : official journal of the International Stroke Society · 2025Review
- Article
- Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?Physiological reports · 2025Article
- Blood pressure and the risk of diabetes: A longitudinal observational study based on Chinese individuals.Journal of diabetes investigation · 2025Observational
- From First Slip to Second Setback: Intracranial Injury Risk after Recurrent Falls in Older Adults: A Retrospective Cohort Study.Advances in geriatric medicine and research · 2025Article
- Review of Blood Pressure Control in Vulnerable Older Adults: The Role of Frailty and Sarcopenia.Journal of vascular diseases · 2025Article
- Triple Antihypertensive Medication Prediction Score After Intracerebral Hemorrhage (the TRICH Score).Neurology · 2025Article
- Combining body mass index and muscle function in investigating mortality among older hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Impact of the National Essential Public Health Service Package on Blood Pressure Control in Chinese People With Hypertension: Retrospective Population-Based Longitudinal Study.JMIR public health and surveillance · 2025Article
- U-shaped association between blood pressure and all-cause mortality in older adults: the Shizuoka study.Journal of human hypertension · 2025Article
- Baseline and 7-Year longitudinal trajectories of systolic blood pressure and all-cause mortality in the elderly: A large prospective cohort study in China, 2017-2023.AIMS public health · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundBlood pressure (BP) management in frail older people is challenging. An randomised controlled trial of largely non-frail older people found cardiovascular and mortality benefit with systolic (S) BP target <120 mmHg. However, all-cause mortality by attained BP in routine care in frail adults aged above 75 is unclear.
objectivesTo estimate observational associations between baseline BP and mortality/cardiovascular outcomes in a primary-care population aged above 75, stratified by frailty.
methodsProspective observational analysis using electronic health records (clinical practice research datalink, n = 415,980). We tested BP associations with cardiovascular events and mortality using competing and Cox proportional-hazards models respectively (follow-up ≤10 years), stratified by baseline electronic frailty index (eFI: fit (non-frail), mild, moderate, severe frailty), with sensitivity analyses on co-morbidity, cardiovascular risk and BP trajectory.
resultsRisks of cardiovascular outcomes increased with SBPs >150 mmHg. Associations with mortality varied between non-frail <85 and frail 75-84-year-olds and all above 85 years. SBPs above the 130-139-mmHg reference were associated with lower mortality risk, particularly in moderate to severe frailty or above 85 years (e.g. 75-84 years: 150-159 mmHg Hazard Ratio (HR) mortality compared to 130-139: non-frail HR = 0.94, 0.92-0.97; moderate/severe frailty HR = 0.84, 0.77-0.92). SBP <130 mmHg and Diastolic(D)BP <80 mmHg were consistently associated with excess mortality, independent of BP trajectory toward the end of life.
conclusionsIn representative primary-care patients aged ≥75, BP <130/80 was associated with excess mortality. Hypertension was not associated with increased mortality at ages above 85 or at ages 75-84 with moderate/severe frailty, perhaps due to complexities of co-existing morbidities. The priority given to aggressive BP reduction in frail older people requires further evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.