ArticleMedicine and pharmacy reports2020
Diabetogenic effect of gluten in Wistar albino rats: a preliminary preclinical screening.
Article in Medicine and pharmacy reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- The Effects of Gluten on Weight Gain, Hematological, Biochemical, and Various Endocrinological Parameters.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Efficacy of 15% lysine cream in treating diabetic foot ulcers: a randomized interventional study.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Characterization of antidepressant activity ofAmerican journal of translational research · 2022Article
- Acute and chronic toxicity studies on ethanolic leaf extracts ofInternational journal of biochemistry and molecular biology · 2022Article
- Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model.International journal of clinical and experimental pathology · 2022Article
- Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study.Reports of biochemistry & molecular biology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsGluten-related disease affects less than 1% population and is not considered of relevance at the public health level. However, the consumption of a gluten-free diet has been most commonly adopted as a special diet worldwide in the recent past. In the present study, we investigated the association of gluten intake and diabetes in Wistar albino rats.
methodsThirty adult Wistar rats were randomly divided into five groups: control, diabetic, and test treated with pure gluten (100, 200 and 400 mg/kg body weight). Diabetes was induced in rats by intraperitoneal injection of Streptozotocin (65 mg/kg) after a dose of nicotinamide (110 mg/kg). Body weight, fasting blood glucose levels, postprandial blood glucose levels and histopathology of the pancreas were compared.
resultsFasting blood glucose levels and postprandial blood glucose were significantly higher in diabetes animals but there were no significant changes in gluten treated groups. Other parameters were not significantly changed among different groups.
conclusionsGluten at doses 100 mg/kg, 200 mg/kg and 400 mg/kg is not a diabetogenic diet and hence it needs not be excluded from diet for the prevention and management of Type 2 diabetes mellitus.
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Registered trials
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