Evidence map›Paper›PMID 32133408›Full record

ArticleScience advances2020

Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism.

Jessica Jones-Carson, Atsushi Yahashiri, Ju-Sim Kim, Lin Liu, Liam F Fitzsimmons, David S Weiss, Andrés Vázquez-Torres

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Association betweenAntioxidants (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. NO-StressedInfection and immunity · 2022
    Article
  14. Article
  15. Manganese Utilization inFrontiers in cell and developmental biology · 2022
    Review
  16. Article
  17. Antimicrobial nanomedicine for ocular bacterial and fungal infection.Drug delivery and translational research · 2021
    Review
  18. Cysteine Proteome Reveals Response to Endogenous Oxidative Stress inInternational journal of molecular sciences · 2021
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jessica Jones-CarsonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-3466-6244
Atsushi YahashiriDepartment of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-7509-2347
Ju-Sim KimDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-4932-4490
Lin LiuDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.
Liam F FitzsimmonsDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-3687-7544
David S WeissDepartment of Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-2217-0070
Andrés Vázquez-TorresDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-6181-4185
University of Colorado Denver · USUniversity of Iowa · USVA Eastern Colorado Health Care System · US

Funding

Salmonella evasion of NADPH oxidase-dependent killingR01AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2003 to 2018
$5.2M
Molecular determinants of oxidative stress in Salmonella pathogenesisR01AI136520 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Andres Vazquez-Torres · 2018 to 2026
$3.7M
Molecular Pathogenesis of Infectious DiseasesT32AI052066 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAN DYK, LINDA F. · 2002 to 2022
$2.3M
Peptidoglycan binding protein specificity and bacterial cell divisionR01GM125656 · NIGMS · UNIVERSITY OF IOWA · PI WEISS, DAVID S · 2018 to 2021
$1.3M
Generalizing RCT Efficacy Evidence: Application to NIDA Clinical Trials NetworkR01DA036520 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOJTABAI, RAMIN · 2014 to 2016
$723k
Analysis of intracellular host defenses in Salmonella pathogenesisR56AI054959 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 2008 to 2008
$378k
Regulation of Nucleotide Pools Mediates Recovery from Nitric Oxide-Induced Cytotoxicity in SalmonellaF31AI118223 · NIAID · UNIVERSITY OF COLORADO DENVER · PI FITZSIMMONS, LIAM FRY · 2016 to 2017
$62k
IRON STORAGE PROTEINS AND SALMONELLA PATHOGENESISF32AI010181 · NIAID · UNIVERSITY OF COLORADO DENVER · PI VAZQUEZ-TORRES, ANDRES · 1998 to 2000
$46k
Molecular Analysis of Bacterial Adaptive Response to Host Reactive SpeciesI01BX002073 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI Andres Vazquez-Torres · 2013 to 2026
–
BLRD VA I01 BX002073NIAID NIH HHS F31 AI118223NIAID NIH HHS F32 AI010181NIAID NIH HHS R01 AI054959NIAID NIH HHS R01 AI136520NIAID NIH HHS R56 AI054959NIAID NIH HHS T32 AI052066NIDA NIH HHS R01 DA036520NIGMS NIH HHS R01 GM125656
6 · The paper itself

Abstract

Cytostasis is the most salient manifestation of the potent antimicrobial activity of nitric oxide (NO), yet the mechanism by which NO disrupts bacterial cell division is unknown. Here, we show that in respiring

Indexed as

Bacillus subtilisBacterial ProteinsCytokinesisCytoskeletal ProteinsEscherichia coliNitric OxideOxygen ConsumptionProton-Motive ForceSalmonellaBacterial ProteinsCytoskeletal ProteinsFtsZ protein, BacteriaNitric Oxide

Identifiers

PMID32133408
PMCPMC7043908
OpenAlexW3008036018

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.