Evidence map›Paper›PMID 32133368›Full record

ArticleFrontiers in nutrition2020

Directed-Mutagenesis of

Claudia E Osorio, Nuan Wen, Jaime H Mejías, Shannon Mitchell, Diter von Wettstein, Sachin Rustgi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Gluten-degrading bacteria: availability and applications.Applied microbiology and biotechnology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Claudia E OsorioDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, United States.
Nuan WenDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, United States.
Jaime H MejíasCentro Regional de Investigación Carillanca, Instituto de Investigaciones Agropecuarias INIA, Temuco, Chile.
Shannon MitchellDepartment of Biological Systems Engineering, Washington State University, Pullman, WA, United States.
Diter von WettsteinDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, United States.
Sachin RustgiDepartment of Crop and Soil Sciences, Washington State University, Pullman, WA, United States.
Washington State University · USClemson University · USInstituto de Investigaciones Agropecuarias · CL

Funding

Prevention of Celiac Disease by Transgenic Removal of Prolamin T-cell EpitopesR01GM080749 · NIGMS · WASHINGTON STATE UNIVERSITY · PI VON WETTSTEIN, DITER H · 2008 to 2011
$802k
NIGMS NIH HHS R01 GM080749
6 · The paper itself

Abstract

Wheat gluten proteins are the known cause of celiac disease. The repetitive tracts of proline and glutamine residues in these proteins make them exceptionally resilient to digestion in the gastrointestinal tract. These indigested peptides trigger immune reactions in susceptible individuals, which could be either an allergic reaction or celiac disease. Gluten exclusion diet is the only approved remedy for such disorders. Recently, a combination of a glutamine specific endoprotease from barley (EP-B2), and a prolyl endopeptidase from

Indexed as

celiac diseasegliadinglutenasesgluteninsite-directed mutagenesisthermostability

Identifiers

PMID32133368
PMCPMC7040222
OpenAlexW3008638780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.