ArticleBiomedical optics express2020
Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions.APL bioengineering · 2024Article
- A novel stress sensor enables accurate estimation of micro-scale tissue mechanics in quantitative micro-elastography.APL bioengineering · 2024Article
- Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- 3D Volumetric Mechanosensation of MCF7 Breast Cancer Spheroids in a Linear Stiffness Gradient GelAGE.Advanced healthcare materials · 2023Article
- Analysis of friction in quantitative micro-elastography.Biomedical optics express · 2023Article
- Recent advances in optical elastography and emerging opportunities in the basic sciences and translational medicine [Invited].Biomedical optics express · 2023Review
- Mechanosensation mediates volume adaptation of cardiac cells and spheroids in 3D.Materials today. Bio · 2022Article
- Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography.Biomedical optics express · 2022Article
- Analysis of strain estimation methods in phase-sensitive compression optical coherence elastography.Biomedical optics express · 2022Article
- Nondestructive testing of native and tissue-engineered medical products: adding numbers to pictures.Trends in biotechnology · 2022Review
- Technological perspectives on laser speckle micro-rheology for cancer mechanobiology research.Journal of biomedical optics · 2021Article
- Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues.Biophysical reviews · 2021Review
- Static compression optical coherence elastography to measure the mechanical properties of soft contact lenses.Biomedical optics express · 2021Article
- Analysis of sensitivity in quantitative micro-elastography.Biomedical optics express · 2021Article
- Quantitative measurement of mechanical properties in wound healing processes in a corneal stroma model by using vibrational optical coherence elastography (OCE).Biomedical optics express · 2021Article
- Camera-based optical palpation.Scientific reports · 2020Article
- Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography.Scientific reports · 2020Article
- Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies in mechanobiology have revealed the importance of cellular and extracellular mechanical properties in regulating cellular function in normal and disease states. Although it is established that cells should be investigated in a three-dimensional (3-D) environment, most techniques available to study mechanical properties on the microscopic scale are unable to do so. In this study, for the first time, we present volumetric images of cellular and extracellular elasticity in 3-D biomaterials using quantitative micro-elastography (QME). We achieve this by developing a novel strain estimation algorithm based on 3-D linear regression to improve QME system resolution. We show that QME can reveal elevated elasticity surrounding human adipose-derived stem cells (ASCs) embedded in soft hydrogels. We observe, for the first time in 3-D, further elevation of extracellular elasticity around ASCs with overexpressed TAZ; a mechanosensitive transcription factor which regulates cell volume. Our results demonstrate that QME has the potential to study the effects of extracellular mechanical properties on cellular functions in a 3-D micro-environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.