Evidence map›Paper›PMID 32133128›Full record

ArticleLight, science & applications2020

High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser.

Cihang Kong, Christian Pilger, Henning Hachmeister, Xiaoming Wei, Tom H Cheung, Cora S W Lai, Nikki P Lee, Kevin K Tsia, Kenneth K Y Wong, Thomas Huser

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Cihang Kong *1Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Christian Pilger *2Biomolecular Photonics, Department of Physics, University of Bielefeld, Universitätsstr, 25, 33615 Bielefeld, Germany.
Henning Hachmeister *2Biomolecular Photonics, Department of Physics, University of Bielefeld, Universitätsstr, 25, 33615 Bielefeld, Germany.
Xiaoming Wei1Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID 0000-0001-6136-5335
Tom H Cheung3Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Cora S W Lai4Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
Nikki P Lee5Department of Surgery, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Kevin K Tsia1Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID 0000-0002-6394-9657
Kenneth K Y Wong1Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID 0000-0003-3668-3539
Thomas Huser2Biomolecular Photonics, Department of Physics, University of Bielefeld, Universitätsstr, 25, 33615 Bielefeld, Germany.ORCID 0000-0003-2348-7416
Bielefeld University · DEUniversity of Hong Kong · HKCalifornia Institute of Technology · USHong Kong University of Science and Technology · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coherent Raman scattering (CRS) microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast, high spatial and spectral resolution, and high sensitivity. However, the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints. Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging, as previous implementations have suffered from high intensity noise, a narrow tuning range and low power, resulting in low image qualities and slow imaging speeds. Here, we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability (improved by 50 dB), timing jitter (24.3 fs), average power fluctuation (<0.5%), modulation depth (>20 dB) and pulse width variation (<1.8%) over an extended wavenumber range (2700-3550 cm

Indexed as

Confocal microscopyFibre lasers

Identifiers

PMID32133128
PMCPMC7039946
OpenAlexW3007153286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.