ArticleFrontiers in neurology2020
Brain Resting-State Network Alterations Associated With Crohn's Disease.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
- Altered resting-state brain functional activities and networks in Crohn's disease: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Trial
- Brain network correlates of fatigue, depression, and anxiety in patients with Crohn's Disease in different disease states.BMC gastroenterology · 2026Article
- Neural fingerprint of the dark triad: Resting state BOLD power (fALFF) alterations in executive and default mode networks.Cognitive, affective & behavioral neuroscience · 2026Article
- Abnormal structural changes and disturbed functional connectivity in patients with Crohn's disease and abdominal pain: a voxel-based morphometry and functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2025Article
- A Heavy Feeling in the Stomach: Neural Correlates of Anxiety in Crohn's Disease.Neurogastroenterology and motility · 2025Article
- Differential Association Between Default Mode Network Connectivity and Attachment Styles in Healthy Individuals and Crohn's Disease Patients.Brain and behavior · 2025Article
- Current approaches to studying human resting-state function in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Impact of fatigue in Crohn's disease is negatively related to resting state functional connectivity between the superior parietal lobule and parahippocampal gyrus/hippocampus.Frontiers in human neuroscience · 2025Article
- Review study of alteration functional activities and networks in ulcerative colitis using resting-state fMRI.Frontiers in neurology · 2025Review
- Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn's disease patients: explorative findings from a 7T MRS study.Frontiers in human neuroscience · 2025Article
- Resting-state BOLD temporal variability of the default mode network predicts spontaneous mind wandering, which is negatively associated with mindfulness skills.Frontiers in human neuroscience · 2025Article
- Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease.Journal of inflammation research · 2024Article
- Evidence linking gut-brain axis and Crohn's disease, focusing on neurotrophic dysfunctions and radiological imaging analysis - a systematic review.American journal of translational research · 2024Article
- Structural brain morphometry differences and similarities between young patients with Crohn's disease in remission and healthy young and old controls.Frontiers in neuroscience · 2024Article
- Sparse Bayesian modeling of hierarchical independent component analysis: Reliable estimation of individual differences in brain networks.Biometrics · 2023Article
- Multimodal Brain MRI of Deep Gray Matter Changes Associated With Inflammatory Bowel Disease.Inflammatory bowel diseases · 2023Article
- Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023Article
- An examination of resting-state functional connectivity in patients with active Crohn's disease.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Region of interest (ROI) analyses were run to assess FC for resting-state network nodes. Independent component analysis (ICA) identified whole brain differences in FC associated with resting-state networks. Though no structural differences were found, ROI analyses showed increased FC between the frontoparietal (FP) network and salience network (SN), and decreased FC between nodes of the default mode network (DMN). ICA results revealed changes involving cerebellar (CER), visual (VIS), and SN components. Differences in FC associated with sex were observed for both ROI analysis and ICA. Taken together, these changes are consistent with an influence of CD on the brain and serve to direct future research hypotheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.