ArticleFrontiers in physiology2020
Glycemia Regulation: From Feedback Loops to Organizational Closure.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Regulation in ecological systems: an overview.History and philosophy of the life sciences · 2025Review
- Embracing the Multifaceted Roles of Biomolecules in Biology and Medicine.Biomolecules · 2025Article
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- Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Integrating Multicellular Systems: Physiological Control and Degrees of Biological Individuality.Acta biotheoretica · 2023Article
- Preptin Deficiency Does Not Protect against High-Fat Diet-Induced Metabolic Dysfunction or Bone Loss in Mice.JBMR plus · 2023Article
- Why it hurts: with freedom comes the biological need for pain.Animal cognition · 2023Article
- Health and environment from adaptation to adaptivity: a situated relational account.History and philosophy of the life sciences · 2022Article
- Diet-Induced Metabolic Dysfunction of Hypothalamic Nutrient Sensing in Rodents.International journal of molecular sciences · 2022Review
- Scaffolding layered control architectures through constraint closure: insights into brain evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Enactive and simondonian reflections on mental disorders.Frontiers in psychology · 2022Article
- From Wingspread to CLARITY: a personal trajectory.Nature reviews. Endocrinology · 2021Review
- Grounding cognition: heterarchical control mechanisms in biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The Causal Closure of Physics in Real World Contexts.Foundations of physics · 2020Article
- Multiscalar Temporality in Human Behaviour: A Case Study of Constraint Interdependence in Psychotherapy.Frontiers in psychology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range. Here, we put forward a different, organicist perspective on the endocrine regulation of glycaemia, by relying on the pivotal concept of closure of constraints. From this perspective, biological systems are understood as organized ones, which means that they are constituted of a set of mutually dependent functional structures acting as constraints, whose maintenance depends on their reciprocal interactions. Closure refers specifically to the mutual dependence among functional constraints in an organism. We show that, when compared to feedback loops, organizational closure can generate much richer descriptions of the processes and constraints at play in the metabolism and regulation of glycaemia, by making explicit the different hierarchical orders involved. We expect that the proposed theoretical framework will open the way to the construction of original mathematical models, which would provide a better understanding of endocrine regulation from an organicist perspective.
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