Evidence map›Paper›PMID 32132878›Full record

ArticleThe Cochrane database of systematic reviews2020

Statins for Smith-Lemli-Opitz syndrome.

Rami A Ballout, Simona Bianconi, Alicia Livinski, Yi-Ping Fu, Alan T Remaley, Forbes D Porter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Cochrane database of systematic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Statins for Smith-Lemli-Opitz syndrome.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Smith-Lemli-Opitz Syndrome: Bosnian and Herzegovinian Experience.Balkan journal of medical genetics : BJMG · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rami A BalloutLipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Simona BianconiNational Institute of Child Health and Development, NIH, Bethesda, USA.
Alicia LivinskiDivision of Library Services, National Institutes of Health Library, Office of Research Services, Bethesda, Maryland, USA.
Yi-Ping FuOffice of Biostatistics Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, USA.
Alan T RemaleyLipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, USA.
Forbes D PorterDivision of Translational Research, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA.
National Heart Lung and Blood Institute · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · US

Funding

Clinical Investigations of Inborn Errors of MetabolismZIAHD008989 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PORTER, FORBES · 2020 to 2025
$5.1M
Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: 1. To evaluate the efficacy of statin therapy in reducing the frequency or severity of the neurobehavioral abnormalities seen in people with SLOS (e.g. aggression, anxiety, irritability, self-mutilation, autistic behaviors, sleep disturbances, etc.) (Wassif 2017). 2. To evaluate the potential effects of statin therapy on survival.

Identifiers

PMID32132878
PMCPMC7055734
OpenAlexW2998793403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.