ArticleNature2020
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
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Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 412 papers.
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412citing papers in PubMed
35.5field-weighted citation impact, top 1% of its field
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Who cites it
412 citing papers in PubMed, 626 citations in OpenAlex.
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- Regulation of cellular proteostasis via mitochondrial protein import.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Peroxisomal Import Stress Drives Cellular Senescence through SCAF1-dependent Suppression of Mitoribosome Biogenesis.bioRxiv : the preprint server for biology · 2026Article
- Integrated stress response activation in combination PG3 and cisplatin-treatedbioRxiv : the preprint server for biology · 2026Article
- Mitochondrial depolarization stabilizes the vitamin BProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cortical organoids reveal human-specific role of METTL5 in neurodevelopment via regulation of CHCHD2.Stem cell reports · 2026Article
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- Metabolites with a message: impacts on epigenetics and implications for epimetabopathies.EMBO reports · 2026Review
- A multilayered stress-response circuit: The mammalian mitochondrial UPR.The FEBS journal · 2026Review
- Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart Failure.International journal of molecular sciences · 2026Review
- Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response.Science advances · 2026Article
- OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity.The EMBO journal · 2026Article
- Mitochondrial quality control in health and disease: mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Spatial control of mitochondrial retrograde signaling by nuclear pore-associated contact sites.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial-Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance.Molecular neurobiology · 2026Review
- Specific FbioRxiv : the preprint server for biology · 2026Article
- MiR-8159-x and miR-200-z induced liver injury of tsinling lenok trout through endoplasmic reticulum and mitochondria interaction under high-temperature stress.Fish physiology and biochemistry · 2026Article
- A transport-independent role for SLC25A12 in mitochondrial stress signalling.Nature cell biology · 2026Article
352 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Xiaoyan GuoInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Giovanni AvilesInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6768-1985
Yi LiuDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Ruilin TianInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Bret A UngerChan Zuckerberg Biohub, San Francisco, CA, USA.
Yu-Hsiu T LinDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7157-4330
Arun P WiitaDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7465-6964
Ke XuChan Zuckerberg Biohub, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2788-194X
M Almira CorreiaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Martin KampmannInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.ORCID http://orcid.org/0000-0002-3819-7019
University of California, San Francisco · USChan Zuckerberg Initiative (United States) · US
Funding
HEPATIC DEGRADATION OF P450P ISOZYMESR01GM044037 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 1990 to 2023
$8.0MREGULATION OF HEME METABOLISM IN THE LIVERR01DK026506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 1986 to 2016
$7.1MRewiring of the human protein homeostasis network in normal and disease contextsDP2GM119139 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAMPMANN, MARTIN · 2015 to 2015
$2.3MIn vivo monitoring of oxidative protein folding through time-resolved quantitative mass spectrometryDP2GM123500 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIITA, ARUN P. · 2016 to 2016
$1.9MInfluence of Heme on Hepatic Cytochrome P450 Synthesis and DegradationR56DK026506 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CORREIA, MARIA ALMIRA · 2007 to 2007
$500kNIDDK NIH HHS R01 DK026506NIDDK NIH HHS R56 DK026506NIGMS NIH HHS DP2 GM119139NIGMS NIH HHS DP2 GM123500NIGMS NIH HHS R01 GM044037NIH HHS 1S10OD010786-01NIH HHS DK26506NIH HHS GM119139NIH HHS GM44037NIH HHS OD022552
Abstract
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the induction of the transcription factor ATF4
Indexed as
Stress, PhysiologicalActivating Transcription Factor 4Cell LineCRISPR-Cas SystemsCytosoleIF-2 KinaseEnzyme ActivationEukaryotic Initiation Factor-2HumansMaleMetalloendopeptidasesMitochondriaMitochondrial ProteinsMolecular ChaperonesPhosphorylationProtein BindingActivating Transcription Factor 4ATF4 protein, humanDELE1 protein, humanEIF2AK1 protein, humaneIF-2 KinaseEukaryotic Initiation Factor-2MetalloendopeptidasesMitochondrial ProteinsMolecular Chaperonesmolecule metalloprotease-related protein-1, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.