ArticleThe ISME journal2020
The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Integrated Optimization, Genomic Characterization, and Functional Evaluation of Biogenic Selenium Nanoparticles fromInternational journal of molecular sciences · 2026Article
- From hijackers to architects: the role of prophages in bacterial genome evolution.Journal of bacteriology · 2026Review
- Whole-Genome Sequencing and Comparative Genomic Analysis ofVeterinary sciences · 2026Article
- Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome.Environmental microbiology reports · 2026Article
- Metabolomics analysis reveals diverse nematicidal metabolites from spore-forming bacteria.AIMS microbiology · 2026Article
- Bioinformatic Identification of CRISPR-Cas Systems inPathogens (Basel, Switzerland) · 2025Article
- Distribution of Genetic Determinants Associated with CRISPR-Cas Systems and Resistance to Antibiotics in the Genomes of Archaea and Bacteria.Microorganisms · 2025Article
- Genome analysis reveals a biased distribution of virulence and antibiotic resistance genes in the genusApplied and environmental microbiology · 2025Article
- Biocontrol Effect ofMicroorganisms · 2025Article
- Antiviral defence arsenal across members of the Bacillus cereus group.Scientific reports · 2025Article
- Article
- Genomic Characterization ofMicroorganisms · 2024Article
- Mosquitocidal toxin-like islands in Bacillus thuringiensis S2160-1 revealed by complete-genome sequence and MS proteomic analysis.Scientific reports · 2024Article
- Analysis of twelve genomes of the bacteriumPeerJ · 2024Article
- The highly diverse antiphage defence systems of bacteria.Nature reviews. Microbiology · 2023Review
- Article
- The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria.Microbiology spectrum · 2023Article
- CRISPR-Cas systems: role in cellular processes beyond adaptive immunity.Folia microbiologica · 2022Review
- Distribution of CRISPR-Cas systems in the Burkholderiaceae family and its biological implications.Archives of microbiology · 2022Article
- Genome sequence of the entomopathogenic Serratia entomophila isolate 626 and characterisation of the species specific itaconate degradation pathway.BMC genomics · 2022Article
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10 authors.
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Abstract
CRISPR-Cas systems are considered as barriers to horizontal gene transfer (HGT). However, the influence of such systems on HGT within species is unclear. Also, little is known about the impact of CRISPR-Cas systems on bacterial evolution at the population level. Here, using Bacillus cereus sensu lato as model, we investigate the interplay between CRISPR-Cas systems and HGT at the population scale. We found that only a small fraction of the strains have CRISPR-Cas systems (13.9% of 1871), and most of such systems are defective based on their gene content analysis. Comparative genomic analysis revealed that the CRISPR-Cas systems are barriers to HGT within this group, since strains harboring active systems contain less mobile genetic elements (MGEs), have lower fraction of unique genes and also display limited environmental distributions than strains without active CRISPR-Cas systems. The introduction of a functional CRISPR-Cas system into a strain lacking the system resulted in reduced adaptability to various stresses and decreased pathogenicity of the transformant strain, indicating that B. cereus group strains could benefit from inactivating such systems. Our work provides a large-scale case to support that the CRISPR-Cas systems are barriers to HGT within species, and that in the B. cereus group the inactivation of CRISPR-Cas systems correlated with acquisition of MGEs that could result in better adaptation to diverse environments.
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