Evidence map›Paper›PMID 32132534›Full record

ArticleNature communications2020

Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices.

Yuanhao Wu, Babatunde O Okesola, Jing Xu, Ivan Korotkin, Alice Berardo, Ilaria Corridori, Francesco Luigi Pellerej di Brocchetti, Janos Kanczler, Jingyu Feng, Weiqi Li and 14 more

Abstract readVideo-Audio Media
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Yuanhao WuInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0002-3955-6474
Babatunde O OkesolaInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0003-0392-9205
Jing XuInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
Ivan KorotkinSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Alice BerardoLaboratory of Bio-inspired, Bionic, Nano, Meta Materials & Mechanics, Università di Trento, via Mesiano, 77, I-38123, Trento, Italy.ORCID http://orcid.org/0000-0002-2346-0507
Ilaria CorridoriLaboratory of Bio-inspired, Bionic, Nano, Meta Materials & Mechanics, Università di Trento, via Mesiano, 77, I-38123, Trento, Italy.ORCID http://orcid.org/0000-0002-7348-9578
Francesco Luigi Pellerej di BrocchettiResearch Center'E. Piaggio' & Dipartimento di Ingegneria dell'Informazione, University of Pisa, Largo Lucio Lazzarino, 256126, Pisa, Italy.
Janos KanczlerBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Jingyu FengSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Weiqi LiInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
Yejiao ShiInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0002-1648-0833
Vladimir FarafonovDepartment of Physical Chemistry, V. N. Karazin Kharkiv National University, Svobody Sq. 4, Kharkiv, 61022, Ukraine.ORCID http://orcid.org/0000-0003-0785-9582
Yiqiang WangUnited Kingdom Atomic Energy Authority, Culham Science Centre, Abingdon, OX14 3DB, UK.
Rebecca F ThompsonThe Astbury Biostructure Laboratory, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-4254-8854
Maria-Magdalena TitiriciSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0003-0773-2100
Dmitry NerukhSystems Analytics Research Institute, Department of Mathematics, Aston University, Birmingham, B4 7ET, UK.ORCID http://orcid.org/0000-0001-9005-9919
Sergey KarabasovSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Richard O C OreffoBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.ORCID http://orcid.org/0000-0001-5995-6726
Jose Carlos Rodriguez-CabelloBIOFORGE Group, University of Valladolid, CIBER-BBN, 47011, Valladolid, Spain.
Giovanni VozziResearch Center'E. Piaggio' & Dipartimento di Ingegneria dell'Informazione, University of Pisa, Largo Lucio Lazzarino, 256126, Pisa, Italy.ORCID http://orcid.org/0000-0002-9414-9994
Helena S AzevedoInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0002-5470-1844
Nicola M PugnoSchool of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.ORCID http://orcid.org/0000-0003-2136-2396
Wen WangInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK.
Alvaro MataInstitute of Bioengineering, Queen Mary University of London, London, E1 4NS, UK. a.mata@nottingham.ac.uk.

Funding

Medical Research Council MR/R015651/1Wellcome TrustWellcome Trust 108466/Z/15/Z
6 · The paper itself

Abstract

Supramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into functional materials and devices. Harnessing the inherent properties of both disordered proteins and graphene oxide (GO), we report a disordered protein-GO co-assembling system that through a diffusion-reaction process and disorder-to-order transitions generates hierarchically organized materials that exhibit high stability and access to non-equilibrium on demand. We use experimental approaches and molecular dynamics simulations to describe the underlying molecular mechanism of formation and establish key rules for its design and regulation. Through rapid prototyping techniques, we demonstrate the system's capacity to be controlled with spatio-temporal precision into well-defined capillary-like fluidic microstructures with a high level of biocompatibility and, importantly, the capacity to withstand flow. Our study presents an innovative approach to transform rational supramolecular design into functional engineering with potential widespread use in microfluidic systems and organ-on-a-chip platforms.

Indexed as

Lab-On-A-Chip DevicesAnimalsBioprintingCell Culture TechniquesCell LineChick EmbryoChorioallantoic MembraneEquipment Designets-Domain Protein Elk-1GraphiteHumansHuman Umbilical Vein Endothelial CellsHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationPrinting, Three-DimensionalProtein Multimerizationets-Domain Protein Elk-1graphene oxideGraphite

Identifiers

PMID32132534
PMCPMC7055247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.