ArticleMolecular & cellular proteomics : MCP2020
Discovery of a Redox Thiol Switch: Implications for Cellular Energy Metabolism.
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Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
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Who cites it
30 citing papers in PubMed, 43 citations in OpenAlex.
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- S-sulfhydration: Novel insights into the antioxidant and antiinflammation in age-related diseases.Journal of advanced research · 2026Review
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Molecular psychiatry · 2026Article
- Insulin resistance and cognitive decline: the metabolic mechanisms linking type 2 diabetes to Alzheimer's disease.Diabetology international · 2025Review
- Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease.Current issues in molecular biology · 2025Review
- Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome.Research square · 2025Article
- Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation.Antioxidants (Basel, Switzerland) · 2025Review
- Comprehensive Overview of Bottom-Up Proteomics Using Mass Spectrometry.ACS measurement science au · 2024Review
- Mining proteomes for zinc finger persulfidation.RSC chemical biology · 2024Article
- Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Thiol redox proteomics: Characterization of thiol-based post-translational modifications.Proteomics · 2023Review
- Cystine/Glutamate XcChemical research in toxicology · 2023Article
- Defining the S-Glutathionylation Proteome by Biochemical and Mass Spectrometric Approaches.Antioxidants (Basel, Switzerland) · 2022Review
- Identification of Early Salt-Stress-Responsive Proteins in In VitroPlants (Basel, Switzerland) · 2022Article
- Adaptation to chronic ER stress enforces pancreatic β-cell plasticity.Nature communications · 2022Article
- Emerging roles of cystathionine β-synthase in various forms of cancer.Redox biology · 2022Review
- Redox signaling and metabolism in Alzheimer's disease.Frontiers in aging neuroscience · 2022Review
- Characterization of Endogenous and Extruded HACS chemical biology · 2021Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Xing-Huang GaoDepartment of Genetics, Case Western Reserve University, Cleveland, OH. Electronic address: xxg72@case.edu.
Ling LiMass Spectrometry Laboratory for Protein Sequencing, The Lerner Research Institute, Cleveland, OH.
Marc ParisienAlan Edwards Centre for Research on Pain McGill University, Montreal, Canada.
Jing WuDepartment of Genetics, Case Western Reserve University, Cleveland, OH.
Ilya BedermanDepartment of Pediatrics, Case Western Reserve University, Cleveland, OH.
Zhaofeng GaoDepartment of Genetics, Case Western Reserve University, Cleveland, OH.
Dawid KrokowskiDepartment of Genetics, Case Western Reserve University, Cleveland, OH; Department of Molecular Biology, Maria Curie-Sklodowska University, Lublin, Poland.
Steven M ChirieleisonDepartment of Pathology,Case Western Reserve University, OH.
Derek AbbottDepartment of Pathology,Case Western Reserve University, OH.
Benlian WangDepartment of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University, OH.
Peter ArvanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Mark CameronDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, OH.
Mark ChanceDepartment of Nutrition, Center for Proteomics and Bioinformatics, Case Western Reserve University, OH; Case Center for Synchrotron Biosciences, Brookhaven National Laboratory, NY.
Belinda WillardMass Spectrometry Laboratory for Protein Sequencing, The Lerner Research Institute, Cleveland, OH.
Maria HatzoglouDepartment of Genetics, Case Western Reserve University, Cleveland, OH. Electronic address: mxh8@case.edu.
Case Western Reserve University · USBrookhaven National Laboratory · USMaria Curie-Skłodowska University · PLMcGill University Health Centre · CAUniversity of Michigan · US
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MProinsulin Trafficking for Insulin BiosynthesisR01DK048280 · NIDDK · YESHIVA UNIVERSITY · PI ARVAN, PETER · 1994 to 2024
$10.5MRegulation of Gene Expression During StressR01DK053307 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 1998 to 2021
$9.6MTranslational Control by NutrientsR01DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI MARIA HATZOGLOU · 2002 to 2026
$6.3MTranslational Control by Osmotically Active SolutesR37DK060596 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI HATZOGLOU, MARIA · 2011 to 2020
$5.3MImmunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4MHigh-End Instrumentation (HEI) Grant Program (S10)S10OD023436 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2017 to 2017
$873kLTQ-Orbitrap Velos instrumentS10RR031537 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2011 to 2011
$600kNCRR NIH HHS S10 RR031537NIAID NIH HHS T32 AI089474NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK048280NIDDK NIH HHS R01 DK053307NIDDK NIH HHS R01 DK060596NIDDK NIH HHS R37 DK060596NIH HHS S10 OD023436
Abstract
The redox-based modifications of cysteine residues in proteins regulate their function in many biological processes. The gas molecule H
Indexed as
Energy MetabolismActivating Transcription Factor 4AnimalsBiological AssayBiotinCell LineCysteineDisulfidesGlycolysisHepatocytesHumansHydrogen SulfideInsulin-Secreting CellsMass SpectrometryMetabolic Flux AnalysisMitochondriaActivating Transcription Factor 4Atf4 protein, ratBiotinCysteineDisulfidesHydrogen SulfidepersulfidesProteomeSulfhydryl CompoundsSulfideschemoproteomicscysteine modificationsdiabetesenergy metabolismglutathionylationH2SpersulfidationPost-translational modificationsprotein sulfhydromequantificationtandem mass spectrometrythiol redox chemistry
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.