ArticleProceedings of the National Academy of Sciences of the United States of America2020
Anterior cingulate cortex is necessary for adaptation of action plans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Success versus failure in cognitive control: Meta-analytic evidence from neuroimaging studies on error processing.Neuroscience and biobehavioral reviews · 2024Pooled it
- Response Flexibility: The Role of the Lateral Habenula.Frontiers in behavioral neuroscience · 2022Pooled it
- Trial
- Anterior cingulate cortex monitors action state and action content in complex associative learning.eLife · 2026Article
- Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development.Molecular psychiatry · 2026Review
- Anterior Cingulate Cortex Mediates State-Dependent Prioritization of Distressed Conspecifics.Brain sciences · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- CB1 receptor signaling at the cingulate-striatal circuit is anxiogenic.Nature communications · 2026Article
- A "personality test" for rats reveals subtle but distinct effects of sex and early life inflammation on brain and behavior.Behavioral neuroscience · 2026Article
- Metabotropic glutamate receptor 5 in the anterior cingulate cortex predicts individual differences in motor impulsivity but not in risky decision-making.Translational psychiatry · 2026Article
- Chronic neuropathic pain alters reversal learning and prefrontal cortex activation without generalized deficits in reward-related behavior.bioRxiv : the preprint server for biology · 2026Article
- The Tap-to-Safety Task: A Novel fMRI Paradigm Assessing Repetitive Threat-Neutralization.Human brain mapping · 2026Article
- Altered Fronto-Cingulate Connectivity During Social Competition and Cooperation in Adolescents With Major Depressive Disorder: An fNIRS Hyperscanning Study.Depression and anxiety · 2026Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- GluR2 overexpression in ACC glutamatergic neurons alleviates cancer-induced bone pain in rats.Molecular medicine (Cambridge, Mass.) · 2025Article
- Healthy aging in rats is associated with a decline in the ability to inhibit maladaptive responses, but not in measures of self-control by delayed gratification.Frontiers in aging neuroscience · 2025Article
- Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations.Biomedicines · 2024Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- The Projection-Specific Noradrenergic Modulation of Perseverative Spatial Behavior in Adult Male Rats.eNeuro · 2024Article
- Anterior cingulate cortex lesions impair multiple facets of task engagement not mediated by dorsomedial striatum neuron firing.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Previous research has focused on the anterior cingulate cortex (ACC) as a key brain region in the mitigation of the competition that arises from two simultaneously active signals. However, to date, no study has demonstrated that ACC is necessary for this form of behavioral flexibility, nor have any studies shown that ACC acts by modulating downstream brain regions such as the dorsal medial striatum (DMS) that encode action plans necessary for task completion. Here, we performed unilateral excitotoxic lesions of ACC while recording downstream from the ipsilateral hemisphere of DMS in rats, performing a variant of the STOP-signal task. We show that on STOP trials lesioned rats perform worse, in part due to the failure of timely directional action plans to emerge in the DMS, as well as the overrepresentation of the to-be-inhibited behavior. Collectively, our findings suggest that ACC is necessary for the mitigation of competing inputs and validates many of the existing theoretical predictions for the role of ACC in cognitive control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.