Observational studyCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020
Circulating Biomarker Score for Visceral Fat and Risks of Incident Colorectal and Postmenopausal Breast Cancer: The Multiethnic Cohort Adiposity Phenotype Study.
Observational study in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of prediction models for risk of breast cancer.BMC cancer · 2025Pooled it
- The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis.International journal of biological sciences · 2021Pooled it
- Low circulating 25-hydroxyvitamin D level is associated with increased colorectal cancer mortality: a systematic review and dose-response meta-analysis.Bioscience reports · 2020Pooled it
- Abdominal visceral and subcutaneous adipose tissue associations with postmenopausal breast cancer incidence.JNCI cancer spectrum · 2025Trial
- Subcutaneous Adipose Tissue FDG Uptake is Associated with Systemic Inflammatory Indices Independent of Primary-Tumor Metabolic Burden in Breast Cancer.Molecular imaging and biology · 2026Article
- Differential blood DNA methylation loci between Native Hawaiian and White women are associated with dietary patterns and metabolic biomarkers.Scientific reports · 2025Article
- Dual-energy X-ray Absorptiometry-Derived Adiposity and Colorectal Cancer Incidence and Mortality in Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Association of Adiposity Phenotypes With 27-Hydroxycholesterol and Sex Hormones: The Multiethnic Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Associations of Albumin and BMI with Colorectal Cancer Risk in the Southern Community Cohort Study: a Prospective Cohort Study.Journal of racial and ethnic health disparities · 2024Article
- A validated estimate of visceral adipose tissue volume in relation to cancer risk.Journal of the National Cancer Institute · 2024Article
- Effect of Intermittent vs. Continuous Energy Restriction on Visceral Fat: Protocol for The Healthy Diet and Lifestyle Study 2 (HDLS2).Nutrients · 2024Article
- Fat Matters: Exploring Cancer Risk through the Lens of Computed Tomography and Visceral Adiposity.Journal of clinical medicine · 2024Review
- Prediction of future visceral adiposity and application to cancer research: The Multiethnic Cohort Study.PloS one · 2024Article
- Genome-wide association study of abdominal MRI-measured visceral fat: The multiethnic cohort adiposity phenotype study.PloS one · 2023Article
- Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.International journal of epidemiology · 2022Article
- Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.International journal of cancer · 2022Article
- Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study.Clinical Medicine Insights. Oncology · 2022Article
- Biomarker-based visceral adiposity score and incident type 2 diabetes in the multiethnic cohort.Annals of epidemiology · 2021Article
- Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study.Biomolecules · 2021Observational
- Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundVisceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.
methodsWe developed a VAT prediction score by regression equations averaged across 100 least absolute shrinkage and selection operator models in a cross-sectional study of 1,801 older adults in the Multiethnic Cohort (MEC). The score was then used as proxy for VAT in case-control studies of postmenopausal breast (950 case-control pairs) and colorectal (831 case-control pairs) cancer in an independent sample in MEC. Abdominal MRI-derived VAT; circulating biomarkers of metabolic, hormonal, and inflammation dysfunctions; and ORs for incident cancer adjusted for BMI and other risk factors were assessed.
resultsThe final score, composed of nine biomarkers, BMI, and height, explained 11% and 15% more of the variance in VAT than BMI alone in men and women, respectively. The area under the receiver operator curve for VAT >150 cm
conclusionsThe VAT score predicted risks of postmenopausal breast cancer and can be used for risk assessment in diverse populations. IMPACT: These findings provide specific evidence for a role of VAT in breast cancer.
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