Evidence map›Paper›PMID 32132098›Full record

ArticleGenetics2020

Alcohol Causes Lasting Differential Transcription in

Emily Petruccelli, Tariq Brown, Amanda Waterman, Nicolas Ledru, Karla R Kaun

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Learning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Neuroscience insights · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Alcohol and the brain: from genes to circuits.Trends in neurosciences · 2021
    Review
  17. Transcriptional Correlates of Chronic Alcohol Neuroadaptation inFrontiers in behavioral neuroscience · 2021
    Article
  18. The Making of Long-Lasting Memories: A Fruit Fly Perspective.Frontiers in behavioral neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emily PetruccelliDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912 epetruc@siue.edu karla_kaun@brown.edu.ORCID 0000-0002-6911-7157
Tariq BrownDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
Amanda WatermanDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
Nicolas LedruDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912.
Karla R KaunDepartment of Neuroscience, Brown University, Providence, Rhode Island 02912 epetruc@siue.edu karla_kaun@brown.edu.ORCID 0000-0002-8756-9528
Brown University · USSouthern Illinois University Edwardsville · US

Funding

The neural basis of sequential control in human and non-human primatesP20GM103645 · NIGMS · BROWN UNIVERSITY · PI SANES, JEROME N · 2013 to 2022
$22.9M
Notch-dependent microcircuit regulaton of alcohol reward memoryR01AA024434 · NIAAA · BROWN UNIVERSITY · PI KAUN, KARLA R. · 2016 to 2025
$3.9M
NIAAA NIH HHS R01 AA024434NIGMS NIH HHS P20 GM103645
6 · The paper itself

Abstract

Repeated alcohol experiences can produce long-lasting memories for sensory cues associated with intoxication. These memories can problematically trigger relapse in individuals recovering from alcohol use disorder (AUD). The molecular mechanisms by which ethanol changes memories to become long-lasting and inflexible remain unclear. New methods to analyze gene expression within precise neuronal cell types can provide further insight toward AUD prevention and treatment. Here, we used genetic tools in

Indexed as

TranscriptomeAnimalsCentral Nervous System DepressantsDrosophila melanogasterEthanolMemoryMushroom BodiesSensory Receptor CellsSpliceosomesCentral Nervous System DepressantsEthanolalcoholDrosophilamemoryRNA-sequencingsplicing

Identifiers

PMID32132098
PMCPMC7198272
OpenAlexW3009974532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.