Evidence map›Paper›PMID 32131913›Full record

ArticleJournal of the International Neuropsychological Society : JINS2020

Episodic Memory and Hippocampal Volume Predict 5-Year Mild Cognitive Impairment Conversion in Healthy Apolipoprotein ε4 Carriers.

Margaret Abraham, Michael Seidenberg, Dana A Kelly, Kristy A Nielson, John L Woodard, J Carson Smith, Sally Durgerian, Stephen M Rao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Margaret AbrahamDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL60064, USA.
Michael SeidenbergDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL60064, USA.
Dana A KellyDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL60064, USA.
Kristy A NielsonDepartment of Psychology, Marquette University, Milwaukee, WI53226, USA.
John L WoodardDepartment of Psychology, Wayne State University, Detroit, MI48202, USA.
J Carson SmithDepartment of Kinesiology, School of Public Health, University of Maryland, College Park, MD20740, USA.
Sally DurgerianDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI53226, USA.
Stephen M RaoSchey Center for Cognitive Neuroimaging, Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH44195, USA.
Rosalind Franklin University of Medicine and Science · USMedical College of Wisconsin · USCleveland Clinic · USUniversity of Maryland, College Park · USWayne State University · US

Funding

ZONISMIDE IN THE TREATMENT OF SEIZURES IN PATIENTSM01RR000058 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI FRANKLIN, SUZIE · 1985 to 2006
$19.9M
Immune Mechanisms Underlying the Neuroprotective Effects of Physical Activity in Human and Mouse Models of Genetic Risk for Alzheimers DiseaseR01AG022304 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI LAMB, BRUCE T, RAO, STEPHEN MARK · 2003 to 2021
$13.0M
fMRI as an Imaging Biomarker for Preclinical Alzheimer's DiseaseR56AG022304 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI RAO, STEPHEN MARK · 2009 to 2009
$411k
NCRR NIH HHS M01 RR000058NIA NIH HHS R01 AG022304NIA NIH HHS R56 AG022304
6 · The paper itself

Abstract

objectiveThe Apolipoprotein (APOE) ε4 allele increases the risk for mild cognitive impairment (MCI) and dementia, but not all carriers develop MCI/dementia. The purpose of this exploratory study was to determine if early and subtle preclinical signs of cognitive dysfunction and medial temporal lobe atrophy are observed in cognitively intact ε4 carriers who subsequently develop MCI.

methodsTwenty-nine healthy, cognitively intact ε4 carriers (ε3/ε4 heterozygotes; ages 65-85) underwent neuropsychological testing and MRI-based measurements of medial temporal volumes over a 5-year follow-up interval; data were converted to z-scores based on a non-carrier group consisting of 17 ε3/ε3 homozygotes.

resultsAt follow-up, 11 ε4 carriers (38%) converted to a diagnosis of MCI. At study entry, the MCI converters had significantly lower scores on the Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT) Trials 1-5, and RAVLT Immediate Recall compared to non-converters. MCI converters also had smaller MRI volumes in the left subiculum than non-converters. Follow-up logistic regressions revealed that left subiculum volumes and RAVLT Trials 1-5 scores were significant predictors of MCI conversion.

conclusionsResults from this exploratory study suggest that ε4 carriers who convert to MCI exhibit subtle cognitive and volumetric differences years prior to diagnosis.

Indexed as

Apolipoprotein E4Memory, EpisodicAgedAged, 80 and overAtrophyCognitive DysfunctionFemaleHeterozygoteHippocampusHumansMagnetic Resonance ImagingMaleNeuropsychological TestsRisk FactorsApolipoprotein E4Alzheimer diseaseHippocampusLongitudinal studiesMild cognitive impairmentMRIRisk factors

Identifiers

PMID32131913
PMCPMC7423643
OpenAlexW3009230575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.