Evidence map›Paper›PMID 32131900›Full record

ArticleMolecular autism2020

Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers.

Olga Egorova, Robin Myte, Jörn Schneede, Bruno Hägglöf, Sven Bölte, Erik Domellöf, Barbro Ivars A'roch, Fredrik Elgh, Per Magne Ueland, Sven-Arne Silfverdal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Maternal Dietary Factors and the Risk of Autism Spectrum Disorders: A Systematic Review of Existing Evidence.Autism research : official journal of the International Society for Autism Research · 2020
    Pooled it
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Olga EgorovaDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. o_yegorova@yahoo.com.ORCID 0000-0002-0208-2877
Robin MyteDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Jörn SchneedeDepartment of Clinical Pharmacology, Pharmacology and Clinical Neurosciences, Umeå University, Umeå, Sweden.
Bruno HägglöfDepartment of Child and Adolescent Psychiatry, Umea University, Umeå, Sweden.
Sven BölteCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Stockholm, Sweden.
Erik DomellöfDepartment of Psychology, Umeå University, Umeå, Sweden.
Barbro Ivars A'rochDepartment of Child and Adolescent Psychiatry, Umea University, Umeå, Sweden.
Fredrik ElghDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Per Magne UelandBevital AS, Department of Clinical Science, University of Bergen, Bergen, Norway.
Sven-Arne SilfverdalDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Umeå University · SECurtin University · AUHaukeland University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis.

methodsSerum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B

resultsWe found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the biomarkers. Neither inflammation markers nor vitamin D

conclusionsOur findings suggest that high maternal serum folate status during early pregnancy may be associated with the occurrence of ASD in offspring. No inference about physiological mechanisms behind this observation can be made at the present time because blood folate levels may have complex relations with nutritional intake, the cellular folate status and status of other B-vitamins. Therefore, further investigations, which may clarify the potential role and mechanisms of maternal blood folate status in ASD risk and the interplay with other potential risk factors, in larger materials are warranted.

Indexed as

AdultAutism Spectrum DisorderBiomarkersCase-Control StudiesFemaleFolic AcidHumansMaleMothersPregnancyPregnancy Trimester, FirstBiomarkersFolic AcidAutismFolateInflammationOne-carbon metabolismPregnancyVitamin AVitamin BVitamin D

Identifiers

PMID32131900
PMCPMC6964211
OpenAlexW3003568174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.