ArticleBiology direct2020
Genome-based classification of Burkholderia cepacia complex provides new insight into its taxonomic status.
Article in Biology direct, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 90 citations in OpenAlex.
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- Laboratory strategies for the identification of Burkholderia species: From classical phenotyping to advanced genomic and proteomic approaches.Antonie van Leeuwenhoek · 2026Review
- Identifying phenotypic and genetic traits for assessing pathogenic potential and biocontrol capacity in Burkholderia sensu lato strains.The ISME journal · 2026Article
- Pan-genome analysis identifies aFrontiers in microbiology · 2026Article
- Effective therapeutic strategies against Pseudomonas aeruginosa and Burkholderia Cepacia complex infections.Scientific reports · 2025Article
- A Nosocomial Outbreak ofAntibiotics (Basel, Switzerland) · 2025Article
- Real-time investigation of a Burkholderia cenocepacia bacteraemia outbreak in a Vietnamese intensive care unit.The Journal of hospital infection · 2025Article
- An Intensive Care Outbreak Caused byPathogens (Basel, Switzerland) · 2025Article
- Characterization of the Antibiotic and Copper Resistance of Emergent Species of Onion-PathogenicPathogens (Basel, Switzerland) · 2025Article
- Cyclic di AMP phosphodiesterase nanovaccine elicits protective immunity against Burkholderia cenocepacia infection in mice.NPJ vaccines · 2025Article
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- 'Candidatus Pseudomonas auctus' sp. nov. JDE115 isolated from nodules on soybean (Glycines max).PloS one · 2025Article
- Draft genome of hydrocarbon-degraderMicrobiology resource announcements · 2024Article
- Burkholderia cepacia complex nosocomial outbreaks in India: A scoping review.The Indian journal of medical research · 2024Article
- The First Case of a Cat Infected withVeterinary sciences · 2024Article
- Activity of antibiotics against Burkholderia cepacia complex in artificial sputum medium.The Journal of antimicrobial chemotherapy · 2024Article
- Response Surface Methodology-Based Optimization of the Chitinolytic Activity ofMicroorganisms · 2024Article
- Glycoproteomic and proteomic analysis ofMicrobiology spectrum · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate classification of different Burkholderia cepacia complex (BCC) species is essential for therapy, prognosis assessment and research. The taxonomic status of BCC remains problematic and an improved knowledge about the classification of BCC is in particular needed.
methodsWe compared phylogenetic trees of BCC based on 16S rRNA, recA, hisA and MLSA (multilocus sequence analysis). Using the available whole genome sequences of BCC, we inferred a species tree based on estimated single-copy orthologous genes and demarcated species of BCC using dDDH/ANI clustering.
resultsWe showed that 16S rRNA, recA, hisA and MLSA have limited resolutions in the taxonomic study of closely related bacteria such as BCC. Our estimated species tree and dDDH/ANI clustering clearly separated 116 BCC strains into 36 clusters. With the appropriate reclassification of misidentified strains, these clusters corresponded to 22 known species as well as 14 putative novel species.
conclusionsThis is the first large-scale and systematic study of the taxonomic status of the BCC and could contribute to further insights into BCC taxonomy. Our study suggested that conjunctive use of core phylogeny based on single-copy orthologous genes, as well as pangenome-based dDDH/ANI clustering would provide a preferable framework for demarcating closely related species. REVIEWER: This article was reviewed by Dr. Xianwen Ren.
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