Evidence map›Paper›PMID 32131811›Full record

Trial reportBMC endocrine disorders2020

Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study.

Aurelian Bidulescu, Paul C Dinh, Shabir Sarwary, Emily Forsyth, Maya C Luetke, David B King, Jiankang Liu, Sharon K Davis, Adolfo Correa

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC endocrine disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aurelian BidulescuDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA. abidules@indiana.edu.ORCID http://orcid.org/0000-0001-8211-8309
Paul C DinhDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
Shabir SarwaryDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
Emily ForsythDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
Maya C LuetkeDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, 1025 E. 7th Street, Bloomington, IN, 47405, USA.
David B KingHenry M Jackson Foundation for the advancement of Military Medicine, Bethesda, MD, USA.
Jiankang LiuBrigham and Women's Hospital, Boston, MA, USA.
Sharon K DavisNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, Bethesda, MD, USA.
Adolfo CorreaJackson Heart Study at University of Mississippi Medical Center, Jackson, MS, USA.

Funding

Social Exposures and Genetics of Cardiovascular DiseaseZIAHG200393 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI GIBBONS, GARY · 2014 to 2019
$13.1M
6 · The paper itself

Abstract

backgroundGrowing evidence suggests that leptin is critical for glycemic control. Impaired leptin signaling may also contribute to low adiponectin expression in obese individuals. We assessed the association of leptin and adiponectin with incident type 2 diabetes (T2D), their interactions with sex and obesity status, and mediation by insulin resistance.

methodsWe included study participants from the Jackson Heart Study, a prospective cohort of adult African Americans in Jackson, Mississippi, that were free of T2D at the baseline Exam 1. Incident T2D was defined as new cases at Exam 2 or Exam 3. We created separate Cox regression models (hazard ratios per log-transformed ng/mL of leptin and adiponectin) with and without insulin resistance, HOMA-IR. Mediation by insulin resistance was analyzed. Several interactions were assessed, including by sex, HbA1c, and obesity.

resultsAmong our 3363 participants (mean age 53 years, 63% women), 584 developed incident T2D. Leptin was directly associated with incident T2D when modeled without HOMA-IR (HR = 1.29, 95% CI = 1.05-1.58). This direct association between leptin and T2D was significant among men (HR = 1.33, 95% CI = 1.05-1.69), but nonsignificant among women (HR = 1.24, 95% CI = 0.94-1.64); statistical interaction with sex was nonsignificant (p = 0.65). The associations in all participants and in men were nullified by HOMA-IR (HR = 0.99, 95% CI = 0.80-1.22; HR = 1.00, 95% CI = 0.78-1.28, respectively), indicating mediation through insulin resistance (proportion mediated: 1.04), and were not observed in abdominally obese participants. Adiponectin was inversely associated with T2D even after adjustment for HOMA-IR in women (HR = 0.68, 95% CI = 0.55-0.84), but not in men (HR = 0.80, 95% CI = 0.62-1.04). The inverse association was present only among abdominally obese participants, and persisted after adjustment for HOMA-IR.

conclusionsAmong African Americans in the Jackson Heart Study the association of leptin with incident type 2 diabetes was mediated by insulin resistance. This association was present only among abdominally non-obese participants. Differences by sex appeared: men showed a significant association mediated by insulin resistance. Among abdominally obese participants, adiponectin was inversely associated with incident T2D even after adjustment for HOMA-IR. Our results should inform future clinical trials that aim to reduce the burden of type 2 diabetes through the modification of serum levels of leptin and adiponectin.

Indexed as

Insulin ResistanceAdiponectinAdultAgedAged, 80 and overBiomarkersBlack or African AmericanBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIncidenceLeptinLongitudinal StudiesAdiponectinADIPOQ protein, humanBiomarkersBlood GlucoseLeptinAdiponectinAfrican AmericansGenderInsulin resistanceLeptinMediationObesityObservational cohortType 2 diabetes

Identifiers

PMID32131811
PMCPMC7057597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.