Evidence map›Paper›PMID 32131738›Full record

ArticleBMC cardiovascular disorders2020

The diagonal branches and outcomes in patients with anterior ST- elevation myocardial infarction.

Shuning Zhang, Xin Deng, Wenlong Yang, Liping Xia, Kang Yao, Hao Lu, Lei Ge, Li Shen, Aijun Sun, Yunzeng Zou and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Shuning ZhangDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xin DengDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Wenlong YangDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Liping XiaDepartment of cardiology, Shaoxing Shangyu People's Hospital, Zhejiang, China.
Kang YaoDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Hao LuDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Lei GeDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Li ShenDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Aijun SunShanghai Institute of Cardiovascular Diseases, Shanghai Cardiovascular Medical Center, Fudan University, Shanghai, China.
Yunzeng ZouDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Juying QianDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Junbo GeDepartment of cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.ORCID 0000-0002-9360-7332
Sun Yat-sen University · CNFudan University · CNShanghai Medical College of Fudan University · CNShaoxing People's Hospital · CN

Funding

China Young/Middle-Aged Clinical Study Fund-V.G. 2017-CCA-VG-031National Natural Science Foundation of China 81100075National Natural Science Foundation of China 81570317Research Foundation of Zhongshan Hospital 2019ZSYXGG13
6 · The paper itself

Abstract

backgroundThe management of diagonal branch (D) occlusion is still controversary. The association between the flow loss of D and the prognosis remains unclear. We aim to detect the impact of D flow on cardiac function and clinical outcomes in patients with anterior ST-segment elevation myocardial infarction (STEMI).

methodsPatients with anterior STEMI undergoing primary percutaneous coronary intervention (PCI) at our clinic between October 2015 and October 2018were reviewed. Anterior STEMI due to left anterior descending artery (LAD) occlusion with or without loss of the main D flow (TIMI grade 0-1 or 2-3) was enrolled in the analysis. The short- and long-term incidence of major adverse cardiac events (MACEs, a composite of all-cause death, target vessel revascularization and reinfarction) and left ventricular ejection fraction (LVEF) were analyzed.

resultsA total of 392 patients (mean age of 63.9 years) with anterior STEMI treated with primary PCI was enrolled in the study. They were divided into two groups, loss (TIMI grade 0-1, n = 69) and no loss (TIMI grade2-3, n = 323) of D flow, before primary PCI. Compared with the group without loss of D flow, the group with loss of D flow showed a lower LVEF post PCI (41.0% vs. 48.8%, p = 0.003). Meanwhile, loss of D flow resulted in the higher in-hospital, one-month, and 18-month incidence of MACEs, especially in all-cause mortality (all p < 0.05). Landmark analysis further indicated that the significant differences in 18-month outcomes between the two groups mainly resulted from the differences during the hospitalization. In addition, multivariate Cox proportional hazards analysis found that D flow loss before primary PCI was independent factor predicting short- and long-term outcomes in patients with anterior STEMI.

conclusionLoss of the main D flow in anterior STEMI patients was independently associated with the higher in-hospital incidences of MACEs and all-cause death as well as the lower LVEF.

Indexed as

Percutaneous Coronary InterventionAgedAnterior Wall Myocardial InfarctionCoronary CirculationCoronary OcclusionFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesRisk FactorsST Elevation Myocardial InfarctionStroke VolumeTime FactorsTreatment OutcomeDiagonal branchesMajor adverse cardiac eventsPrimary percutaneous coronary interventionST-segment elevation myocardial infarction

Identifiers

PMID32131738
PMCPMC7057519
OpenAlexW3011391406

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.