ArticleJournal of the American Heart Association2020
Cumulative Adherence to Secondary Prevention Guidelines and Mortality After Acute Myocardial Infarction.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Pharmacological treatment after a first myocardial infarction in Sweden-long-term adherence and prognosis.European heart journal. Quality of care & clinical outcomes · 2026Article
- Associations of multiple evidence-based care strategies with disease mortality, life expectancy, and disparities in the United States.Health affairs scholar · 2026Article
- Optimizing low-density lipoprotein cholesterol (LDL-C) management - a US physician survey of barriers and burdens.American journal of preventive cardiology · 2026Article
- Effect of an emergency department-based educational intervention on medication adherence and disease understanding after acute myocardial infarction in Tanzania.Frontiers in public health · 2026Article
- [Pharmacological adherence and cardiometabolic goals in successfully reperfused acute myocardial infarction].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Adherence trajectories of oral lipid-lowering therapy in patients with myocardial infarction and its estimated impact on low-density lipoprotein levels.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- The Rising Tide of Coronary Crisis: Decoding Age-Specific Disparities in Ischemic Heart Disease Burden Through the Global Burden of Disease Study 2021 Revelations: An Ecological Study.Health science reports · 2025Article
- Association of sociodemographic factors and comorbidity with non-receipt of medications for secondary prevention: a cohort study of 12,204 myocardial infarction survivors.BMC medicine · 2025Article
- Impact of NSAIDs corticosteroids DMARDs biologics and their comparisons with natural products in C-reactive proteins (CRP) linked cardiovascular disorders.Inflammopharmacology · 2025Review
- A hospital lipid-lowering protocol improves 2-year clinical outcomes in patients with acute coronary syndrome.AsiaIntervention · 2024Article
- Article
- Long-Term Prognostic Value ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- The importance of low-density lipoprotein cholesterol measurement and control as performance measures: A joint clinical perspective from the National Lipid Association and the American Society for Preventive Cardiology.American journal of preventive cardiology · 2023Review
- Economic Burden Associated with the Treatment with a Cardiovascular Polypill in Secondary Prevention in Spain: Cost-Effectiveness Results of the NEPTUNO Study.ClinicoEconomics and outcomes research : CEOR · 2023Article
- One-Year Outcomes and Factors Associated With Mortality Following Acute Myocardial Infarction in Northern Tanzania.Circulation. Cardiovascular quality and outcomes · 2022Observational
- Willingness to participate in cardiac telerehabilitation: results from semi-structured interviews.European heart journal. Digital health · 2022Article
- Contemporary impact of circadian symptom-onset patterns of acute ST-Segment elevation myocardial infarction on long-term outcomes after primary percutaneous coronary intervention.Annals of medicine · 2021Observational
- Thirty-day outcomes and predictors of mortality following acute myocardial infarction in northern Tanzania: A prospective observational cohort study.International journal of cardiology · 2021Observational
- Adherence to recommendations for secondary prevention medications after myocardial infarction in Estonia: comparison of real-world data from 2004 to 2005 and 2017 to 2018.BMC cardiovascular disorders · 2021Article
- Prognostic impact of mean heart rate by Holter monitoring on long-term outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The survival benefit associated with cumulative adherence to multiple clinical and lifestyle-related guideline recommendations for secondary prevention after acute myocardial infarction (AMI) is not well established. Methods and Results We examined adults with AMI (mean age 68 years; 64% men) surviving at least 30 (N=25 778) or 90 (N=24 200) days after discharge in a large integrated healthcare system in Northern California from 2008 to 2014. The association between all-cause death and adherence to 6 or 7 secondary prevention guideline recommendations including medical treatment (prescriptions for β-blockers, renin-angiotensin-aldosterone system inhibitors, lipid medications, and antiplatelet medications), risk factor control (blood pressure <140/90 mm Hg and low-density lipoprotein cholesterol <100 mg/dL), and lifestyle approaches (not smoking) at 30 or 90 days after AMI was evaluated with Cox proportional hazard models. To allow patients time to achieve low-density lipoprotein cholesterol <100 mg/dL, this metric was examined only among those alive 90 days after AMI. Overall guideline adherence was high (35% and 34% met 5 or 6 guidelines at 30 days; and 31% and 23% met 6 or 7 at 90 days, respectively). Greater guideline adherence was independently associated with lower mortality (hazard ratio, 0.57 [95% CI, 0.49-0.66] for those meeting 7 and hazard ratio, 0.69 [95% CI, 0.61-0.78] for those meeting 6 guidelines versus 0 to 3 guidelines in 90-day models, with similar results in the 30-day models), with significantly lower mortality per each additional guideline recommendation achieved. Conclusions In a large community-based population, cumulative adherence to guideline-recommended medical therapy, risk factor control, and lifestyle changes after AMI was associated with improved long-term survival. Full adherence was associated with the greatest survival benefit.
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