Evidence map›Paper›PMID 32131453›Full record

ArticleMolecules (Basel, Switzerland)2020

In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385.

Jin-Ju Byeon, Min-Ho Park, Seok-Ho Shin, Yuri Park, Byeong Ill Lee, Jang-Mi Choi, Nahye Kim, Seo-Jin Park, Min-Jae Park, Jeong-Hyeon Lim and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jin-Ju ByeonCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Min-Ho ParkCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Seok-Ho ShinCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Yuri ParkCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Byeong Ill LeeCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Jang-Mi ChoiCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Nahye KimCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Seo-Jin ParkCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Min-Jae ParkCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Jeong-Hyeon LimCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.
Young-Guk NaCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.ORCID 0000-0002-7937-1626
Young G ShinCollege of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.ORCID 0000-0002-7135-8988
Chungnam National University · KR

Funding

Ministry of Food and Drug Safety 19172MFDS163
6 · The paper itself

Abstract

Parkinson's disease is one of the most common neurodegenerative diseases. Adenosine regulates the response to other neurotransmitters in the brain regions related to motor function. In the several subtypes of adenosine receptors, especially, adenosine 2A receptors (A

Indexed as

Adenosine A2 Receptor AntagonistsComputer SimulationTriazinesTriazolesAnimalsMaleParkinson DiseaseRatsRats, Sprague-DawleyReceptor, Adenosine A2AAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2ATriazinesTriazolesZM 241385A2A receptor inhibitorLC-qToF MSParkinson’s diseasePBPK modelingpharmacokineticsZM241385

Identifiers

PMID32131453
PMCPMC7179144
OpenAlexW3009887683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.