Observational studyNutrients2020
The Course Of IGF-1 Levels and Nutrient Intake in Extremely and Very Preterm Infants During Hospitalisation.
Observational study in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Analysis of variable metabolites in preterm infants with bronchopulmonary dysplasia: a systematic review and meta-analysis.Italian journal of pediatrics · 2024Pooled it
- Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.Pediatric research · 2023Trial
- Parenteral nutrition use and recurrence requiring retreatment of retinopathy of prematurity after anti-VEGF monotherapy: a retrospective cohort study of preterm infants.BMC pediatrics · 2026Article
- From Blood Count Parameters to ROP Risk: Early Hematological Predictors in Preterm Infants.Medicina (Kaunas, Lithuania) · 2025Article
- Article
- Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Nutritional interventions to prevent retinopathy of prematurity.Pediatric research · 2024Review
- Associations between Bronchopulmonary Dysplasia, Insulin-like Growth Factor I and Nutrition.Nutrients · 2024Observational
- Hormonal Determinants of Growth and Weight Gain in the Human Fetus and Preterm Infant.Nutrients · 2023Review
- Inflammation induces stunting by lowering bone mass via GH/IGF-1 inhibition in very preterm infants.Pediatric research · 2023Article
- Percentile-Based Reference Values of Umbilical Cord Blood Insulin-like Growth Factor 1 in Japanese Newborns.Journal of clinical medicine · 2022Article
- Analysis of "true extrauterine growth retardation" and related factors in very preterm infants-A multicenter prospective study in China.Frontiers in pediatrics · 2022Article
- Nutritional Intake, White Matter Integrity, and Neurodevelopment in Extremely Preterm Born Infants.Nutrients · 2021Article
- Early Nutrition during Hospitalization in Relation to Bone Health in Preterm Infants at Term Age and Six Months Corrected Age.Nutrients · 2021Article
- Metabolic Hormone Profiles in Breast Milk From Mothers of Moderate-Late Preterm Infants Are Associated With Growth From Birth to 4 Months in a Sex-Specific Manner.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin-like growth factor 1 (IGF-1) plays an important role in the complex association between nutrition, growth, and maturation in extremely and very preterm infants. Nevertheless, in this population, research on associations between IGF-1 and nutrition is limited. Therefore this study aimed to evaluate the possible associations between the course of IGF-1 levels and nutrient intake between preterm birth and 36 weeks postmenstrual age (PMA).
methods87 infants born between 24 and 32 weeks gestational age were followed up to 36 weeks PMA. Actual daily macronutrient intake was calculated, and growth was assessed weekly. IGF-1 was sampled from umbilical cord blood at birth and every other week thereafter.
resultsThere was an inverse relationship between the amount of parenteral nutrition in the second week of life and IGF-1. Total protein, fat, and carbohydrate intake, as well as total energy intake, primarily showed a positive association with IGF-1 levels, particularly between 30 and 33 weeks PMA. Gestational age, bronchopulmonary dysplasia (BPD), and weight were significant confounders in the association between nutrient intake and IGF-1 levels.
conclusionParenteral nutrition was found to be a negative predictor of IGF-1 levels, and there could potentially be a time frame in which macronutrient intake is unable to impact IGF-1 levels. Future research should aim to narrow down this time frame and to gain more insight into factors enhancing or decreasing the response of IGF-1 to nutrition, e.g., age and inflammatory state, to align nutritional interventions accordingly.
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