Evidence map›Paper›PMID 32131402›Full record

ArticleCancers2020

Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines.

Martin Michaelis, Yvonne Voges, Florian Rothweiler, Fabian Weipert, Amara Zia-Ahmad, Jaroslav Cinatl, Andreas von Deimling, Frank Westermann, Franz Rödel, Mark N Wass and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Martin MichaelisIndustrial Biotechnology Centre and School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0002-5710-5888
Yvonne VogesInstitut für Medizinische Virologie, Goethe-Universität, 60596 Frankfurt am Main, Germany.
Florian RothweilerInstitut für Medizinische Virologie, Goethe-Universität, 60596 Frankfurt am Main, Germany.
Fabian WeipertDepartment of Radiotherapy and Oncology, Goethe-Universität, 60590 Frankfurt am Main, Germany.
Amara Zia-AhmadInstitut für Medizinische Virologie, Goethe-Universität, 60596 Frankfurt am Main, Germany.
Jaroslav CinatlInstitut für Medizinische Virologie, Goethe-Universität, 60596 Frankfurt am Main, Germany.
Andreas von DeimlingDepartment of Neuropathology, Ruprecht-Karls-University Heidelberg and Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany.
Frank WestermannDivision Neuroblastoma Genomics, B087, German Cancer Research Center and Hopp Children´s Cancer Center at the NCT (KiTZ), 69120 Heidelberg, Germany.
Franz RödelDepartment of Radiotherapy and Oncology, Goethe-Universität, 60590 Frankfurt am Main, Germany.
Mark N WassIndustrial Biotechnology Centre and School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0001-5428-6479
Jindrich CinatlInstitut für Medizinische Virologie, Goethe-Universität, 60596 Frankfurt am Main, Germany.
Goethe University Frankfurt · DEGerman Cancer Research Center · DEUniversity of Kent · GB

Funding

Frankfurter Stiftung für krebskranke Kinder n/aHilfe für krebskranke Kinder Frankfurt e.V. n/a
6 · The paper itself

Abstract

The survivin suppressant YM155 is a drug candidate for neuroblastoma. Here, we tested YM155 in 101 neuroblastoma cell lines (19 parental cell lines, 82 drug-adapted sublines). Seventy seven (77) cell lines displayed YM155 IC

Indexed as

ABCB1ABCC1drug resistanceneuroblastomasurvivinYM155

Identifiers

PMID32131402
PMCPMC7139505
OpenAlexW3010064672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.