Evidence map›Paper›PMID 32131368›Full record

Observational studyJournal of musculoskeletal & neuronal interactions2020

Characterisation of peripheral bone mineral density in youth at risk of secondary osteoporosis - a preliminary insight.

Mark Jenkins, Nicolas H Hart, Sophia Nimphius, Paola Chivers, Timo Rantalainen, Karen M Rothacker, Belinda R Beck, Benjamin K Weeks, Fleur McIntyre, Beth Hands and 2 more

Abstract readObservational Study
PubMed Full text at PMC
In one paragraph

Observational study in Journal of musculoskeletal & neuronal interactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Animal, Human, andCurrent pediatrics reports · 2021
    Review
  3. Exploring the brain-body composition relationship in Huntington's disease.Journal of musculoskeletal & neuronal interactions · 2020
    Article
  4. Biological basis of bone strength: anatomy, physiology and measurement.Journal of musculoskeletal & neuronal interactions · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Mark JenkinsSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Nicolas H HartSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Sophia NimphiusSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Paola ChiversSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Timo RantalainenSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Karen M RothackerDepartment of Endocrinology and Diabetes, Perth Children's Hospital, Perth, W.A., Australia.
Belinda R BeckMenzies Health Institute Queensland, Bone Densitometry Research Laboratory, School of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia.
Benjamin K WeeksMenzies Health Institute Queensland, Bone Densitometry Research Laboratory, School of Allied Health Sciences, Griffith University, Gold Coast, QLD, Australia.
Fleur McIntyreWestern Australian Bone Research Collaboration, Perth, W.A., Australia.
Beth HandsWestern Australian Bone Research Collaboration, Perth, W.A., Australia.
Brendan P BeesonDepartment of Medical Imaging, Perth Children's Hospital, Perth, W.A.
Aris SiafarikasSchool of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Edith Cowan University · AUGriffith University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe peripheral long bone material and structural differences in youth at risk of secondary osteoporosis across disease-specific profiles.

methodsUpper- and lower limbs of children and adolescents were scanned at 4% distal and 66% mid-shaft sites using peripheral Quantitative Computed Tomography sub-categorised as (1) increased risk of secondary osteoporosis (neuromuscular disorders; chronic diseases; endocrine diseases; inborn errors of metabolism; iatrogenic conditions), (2) low motor competence and (3) non-affected controls.

resultsChildren with disease-specific profiles showed a range of bone deficits compared to the control group with these predominantly indicated for neuromuscular disorders, chronic diseases and low motor competence. Deficits between upper arm and lower leg long bone parameters were different for disease-specific profiles compared to the control group. Endocortical radius, muscle area, and mid-cortical ring density were not significantly different for any disease-specific profile compared to the control group for any bone sites.

conclusionsNeuromuscular disorders, chronic diseases and low motor competence have a strong correlation to bone health for appendicular bone parameters in youth, suggesting a critical mechanical loading influence which may differ specific to disease profile. As mechanical loading effects are observed in regional bone analyses, targeted exercise interventions to improve bone strength should be implemented to examine if this is effective in reducing the risk of secondary osteoporosis in youth.

Indexed as

AdolescentArm BonesBone DensityChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantLeg BonesMaleOsteoporosisRisk FactorsTomography, X-Ray ComputedWestern AustraliaAppendicularDisorderFragilityMorphologyMovement

Identifiers

PMID32131368
PMCPMC7104582
OpenAlexW2992558890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.