Evidence map›Paper›PMID 32130915›Full record

ArticleCell reports2020

Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr

Sahar Mazhar, Daniel Leonard, Alejandro Sosa, Daniela Schlatzer, Dafydd Thomas, Goutham Narla

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  3. bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sahar MazharDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Daniel LeonardDepartment of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Alejandro SosaCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Daniela SchlatzerCenter for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH 44106, USA.
Dafydd ThomasDepartment of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Goutham NarlaDivision of Genetic Medicine, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: gnarla@med.umich.edu.
Case Western Reserve University · USMichigan Medicine · USUniversity of Michigan · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Structural and molecular determinants of protein phosphatase 2A in Alzheimer's DiseaseR01CA240993 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NARLA, GOUTHAM, TAYLOR, DEREK JAMES · 2019 to 2023
$3.4M
Role of Protein Phosphatase 2A in Aortic AneurysmR01HL144741 · NHLBI · EMORY UNIVERSITY · PI LIN, ZHIYONG, NARLA, GOUTHAM · 2019 to 2022
$2.2M
Small Molecule Activators of PP2A (SMAPs) for Prostate Cancer TherapyR01CA181654 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NARLA, GOUTHAM · 2015 to 2019
$1.9M
Orbitrap Fusion Lumos Tribrid Mass SpectrometerS10OD026882 · OD · CASE WESTERN RESERVE UNIVERSITY · PI CHANCE, MARK R · 2019 to 2019
$1.0M
Overcoming resistance to first generation small molecule activators of PP2A.F30CA224977 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI LEONARD, DANIEL JOHN · 2018 to 2021
$186k
NCI NIH HHS F30 CA224977NCI NIH HHS R01 CA181654NCI NIH HHS R01 CA240993NHLBI NIH HHS R01 HL144741NIGMS NIH HHS T32 GM007250NIH HHS S10 OD026882
6 · The paper itself

Abstract

Aberrant hyperphosphorylation of the protein phosphatase 2A catalytic subunit (PP2Ac) at Tyr

Indexed as

ResearchAlkaline PhosphataseAmino Acid SequenceAntibodiesCell LineCell Line, TumorHumansLeucineMethylationMutationPeptidesPhosphorylationPhosphotyrosineProtein Phosphatase 2Protein Processing, Post-TranslationalVanadatesAlkaline PhosphataseAntibodiesLeucinePeptidesperoxyvanadatePhosphotyrosineProtein Phosphatase 2Vanadatesantibody validationphospho-specific antibodyphospho-Tyr307 PP2AcPP2A

Identifiers

PMID32130915
PMCPMC7156886
OpenAlexW3010581072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.