ArticleCell reports2020
Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 54 citations in OpenAlex.
- Glutamate concentration tunes AMPA receptor function through conductance-state occupancy.Nature neuroscience · 2026Article
- Cerebellar activity is triggered by reach endpoint during learning of a complex locomotor task.Nature communications · 2026Article
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- All-optical voltage interrogation for probing synaptic plasticity in vivo.Nature communications · 2025Article
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Cerebellar basket cell filtering of Purkinje cell responses elicited by low frequency parallel fibre transmission.Scientific reports · 2025Article
- The cerebellar deep nuclei: a patch for rate codes?Frontiers in neural circuits · 2025Article
- Article
- A cerebro-cerebellar network for learning visuomotor associations.Nature communications · 2024Article
- Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory.Molecular psychiatry · 2024Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.eLife · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Heterogeneous encoding of temporal stimuli in the cerebellar cortex.Nature communications · 2023Article
- Afferent convergence to a shared population of interneuron AMPA receptors.Nature communications · 2023Article
- Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs.bioRxiv : the preprint server for biology · 2023Article
- Diverse role of NMDA receptors for dendritic integration of neural dynamics.PLoS computational biology · 2023Article
- Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells.Scientific reports · 2023Article
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood. In the cerebellar cortex, molecular layer interneurons and their targets, Purkinje cells, receive excitatory inputs from granule cells and climbing fibers. Using dual patch-clamp recordings from interneurons and Purkinje cells in vivo, we probe the spatiotemporal interactions between these circuit elements. We show that single interneuron spikes can potently inhibit Purkinje cell output, depending on interneuron location. Climbing fiber input activates many interneurons via glutamate spillover but results in inhibition of those interneurons that inhibit the same Purkinje cell receiving the climbing fiber input, forming a disinhibitory motif. These interneuron circuits are engaged during sensory processing, creating diverse pathway-specific response functions. These findings demonstrate how the powerful effect of single interneurons on Purkinje cell output can be sculpted by various interneuron circuit motifs to diversify cerebellar computations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.