ArticleCell metabolism2020
Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function.
Open access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers.
0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed
16.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
235 citing papers in PubMed, 411 citations in OpenAlex.
- Hydrogen peroxide sensing and signaling in physiology and disease: implications for therapy.Signal transduction and targeted therapy · 2026Review
- Multiomic proximity labeling in vivo by D-amino-acid-activated peroxidase reaction.Nature chemical biology · 2026Article
- Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage.Science advances · 2026Article
- Experimental workflows for the accurate identification of mitochondrial redox events.Redox biology · 2026Review
- Intercellular mitochondrial transfer and trans-mitophagy in response to protein import dysfunction.The Journal of cell biology · 2026Article
- Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.Chembiochem : a European journal of chemical biology · 2026Review
- Protein Surface Site Determines the Evolutionary Accessibility of Allosteric Regulation.bioRxiv : the preprint server for biology · 2026Article
- Vimentin remodeling in response to oxidants and electrophiles is modulated by pH.Science advances · 2026Article
- Beyond DCFH-DA: A Critical Review of Hydrogen Peroxide and Superoxide Detection Strategies in Mammalian Living Systems (2015-2026).International journal of molecular sciences · 2026Review
- Hydrogen Peroxide Imaging via HyPer7 Probe in Adeno Associated Virus-Transduced Primary Mouse Hepatocytes.Current protocols · 2026Article
- KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling.bioRxiv : the preprint server for biology · 2026Article
- Live Visualization of Endoplasmic Reticulum Redox Potential in Zebrafish Embryos Reveals Region-Specific Heterogeneity.Biomedicines · 2026Article
- Preclinical characterization and phase 1 clinical testing of targeting mitochondrial peroxiredoxin 3 in cancer.Nature communications · 2026Article
- 7-ketocholesterol contributes to microglia-driven increases in astrocyte reactive oxygen species in a mouse model of Alzheimer's disease.Scientific reports · 2026Article
- Redox Regulation of Plant-Root-Knot Nematode Interactions: From ROS-Mediated Immunity to Sustainable Resistance.Antioxidants (Basel, Switzerland) · 2026Review
- Plasmodesmata display dynamic local and systemic redox responses during plant stress.The Plant cell · 2026Article
- Ischaemia/reperfusion and permanent ischaemia differentially affect haemoglobin properties - Possible influence of oxidative stress and adaptation to acute hypoxia.The FEBS journal · 2026Article
- Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026Article
- Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial HRedox biology · 2026Article
- Redox signals and oxidative stress in the control of mitochondrial protein import.Protein science : a publication of the Protein Society · 2026Review
175 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 10 institutions in 5 countries.
Valeriy V PakDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; Institute for Cardiovascular Physiology, Georg August University Göttingen, Göttingen 37073, Germany.
Daria EzeriņaVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Olga G LyublinskayaDepartment of Intracellular Signaling and Transport, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
Brandán PedreVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Pyotr A Tyurin-KuzminFaculty of Medicine, Lomonosov Moscow State University, Moscow 119991, Russia.
Natalie M MishinaDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
Marion ThauvinCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris 75231, France; Sorbonne Université, Collège Doctoral, Paris 75005, France.
David YoungVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Khadija WahniVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Santiago Agustín Martínez GacheVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Alexandra D DemidovichDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
Yulia G ErmakovaDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; European Molecular Biology Laboratory, Heidelberg 69117, Germany.
Yulia D MaslovaDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
Arina G ShokhinaDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
Emrah ErogluBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dmitry S BilanDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow 117997, Russia.
Ivan BogeskiInstitute for Cardiovascular Physiology, Georg August University Göttingen, Göttingen 37073, Germany.
Thomas MichelBrigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sophie VrizCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris 75231, France; University Paris-Diderot, Paris 75006, France.
Joris MessensVIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie - Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050 Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Vsevolod V BelousovDepartment of Metabolism and Redox Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow 117997, Russia; Institute for Cardiovascular Physiology, Georg August University Göttingen, Göttingen 37073, Germany; Federal Center for Cerebrovascular Pathology and Stroke, Moscow 117997, Russia. Electronic address: belousov@ibch.ru.
Institute of Bioorganic Chemistry · RUVIB-VUB Center for Structural Biology · BEBrigham and Women's Hospital · USInserm · FRPirogov Russian National Research Medical University · RUUniversity of Göttingen · DEVrije Universiteit Brussel · BEEuropean Molecular Biology Laboratory · DEInstitute of Cytology · RULomonosov Moscow State University · RU
Funding
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MChemogenetic approaches to define the roles of redox dysfunction in the cardiomyopathy of agingR21AG063073 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2019 to 2020
$480kAustrian Science Fund FWF J 4113NIA NIH HHS R21 AG063073NIDDK NIH HHS P30 DK057521
Abstract
Hydrogen peroxide (H
Indexed as
Cell MovementAnimalsBiological TransportCell Surface ExtensionsElectron Transport Complex IHeLa CellsHumansHydrogen PeroxideImaging, Three-DimensionalLarvaMitochondriaMitochondrial MembranesOxidantsZebrafishElectron Transport Complex IHydrogen PeroxideOxidantscell migrationchemogeneticsD-amino acid oxidasegenetically encoded probesH(2)O(2)H(2)O(2) gradientshydrogen peroxideHyPer7mitochondriaredox signaling
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.