Evidence map›Paper›PMID 32130881›Full record

Trial reportCell metabolism2020

Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans.

Jelle R Dalenberg, Barkha P Patel, Raphael Denis, Maria G Veldhuizen, Yuko Nakamura, Petra C Vinke, Serge Luquet, Dana M Small

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06094894 (Changes in Gut Microbiota and Postprandial GLP-1 Concentration Due to Sucralose Consumption), which is not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 4 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06094894 nacompletednot on this mapstarted 2023, after this paper: background citation

Changes in Gut Microbiota and Postprandial GLP-1 Concentration Due to Sucralose Consumption

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2023 to 2024Enrolled40ConditionsGLP-1, Gut Microbiota, Insulin ResistanceArmssucralose, placebo
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  15. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 6 countries.

Jelle R DalenbergModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Barkha P PatelModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Division of Endocrinology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Raphael DenisUnite de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Maria G VeldhuizenModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
Yuko NakamuraModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; The UTokyo Center for Integrative Science of Human Behavior, Tokyo, Japan.
Petra C VinkeModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroendocrinology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Serge LuquetUnite de Biologie Fonctionnelle et Adaptative, Centre National la Recherche Scientifique, Unité Mixte de Recherche 8251, Université Paris Diderot, Sorbonne Paris Cité, 75205 Paris, France.
Dana M SmallModern Diet and Physiology Research Center (MDPRC), Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Psychology, Yale University, New Haven, CT 06510, USA; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Otfried Müller Strasse 47, Tübingen 72076, Germany. Electronic address: dana.small@yale.edu.
Yale University · USGerman Center for Diabetes Research · DESorbonne Paris Cité · FRUniversité Paris Cité · FRUniversity of Groningen · NL

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cognitive and affective influences on taste processingR01DC006706 · NIDCD · YALE UNIVERSITY · PI SMALL, DANA M · 2006 to 2018
$5.3M
NCATS NIH HHS UL1 TR001863NIDCD NIH HHS R01 DC006706
6 · The paper itself

Abstract

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie "diet" drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in healthy human participants, an effect that correlates with reductions in midbrain, insular, and cingulate responses to sweet, but not sour, salty, or savory, taste as assessed with fMRI. Taste perception was unaltered and consuming the carbohydrate alone had no effect. These findings indicate that consumption of sucralose in the presence of a carbohydrate rapidly impairs glucose metabolism and results in longer-term decreases in brain, but not perceptual sensitivity to sweet taste, suggesting dysregulation of gut-brain control of glucose metabolism.

Indexed as

Feeding BehaviorAdultArea Under CurveBrainHumansInsulin ResistanceMiddle AgedPolysaccharidesSucroseSugarsTasteTime FactorsYoung AdultmaltodextrinPolysaccharidesSucroseSugarstrichlorosucrosediabetesfMRIglucose toleranceindirect calorimetryinsulalow-calorie sweetenermidbrainobesitytaste perception

Identifiers

PMID32130881
PMCPMC7784207
OpenAlexW3010146326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.