ArticleNeuron2020
Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 108 citations in OpenAlex.
- An inspiration-off attractor supports the robust and flexible control of breathing.Science advances · 2026Article
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the PreBötzinger Complex of the Ventrolateral Medulla.Molecular neurobiology · 2026Article
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the preBötzinger Complex of the Ventrolateral Medulla.Research square · 2026Article
- Noradrenergic neuromodulation produces a NMDAR-dependent network state of respiratory rhythmogenesis in the preBötzinger Complex.bioRxiv : the preprint server for biology · 2026Article
- How causal is "circular causality"?Frontiers in network physiology · 2026Article
- Review
- Oxytocin modulates respiratory heart rate variability through a hypothalamus-brainstem-heart neuronal pathway.Nature neuroscience · 2025Article
- Astrocytic Connexin43 Channels Are Essential for Breathing Pattern Stabilization in the preBötzinger Complex.CNS neuroscience & therapeutics · 2025Article
- Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- A Computational Model of the Respiratory CPG for the Artificial Control of Breathing.Bioengineering (Basel, Switzerland) · 2025Article
- An inspiration-off attractor supports the robust and flexible control of breathing.bioRxiv : the preprint server for biology · 2025Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Sigh generation in preBötzinger complex.eLife · 2025Article
- Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5.Journal of sleep research · 2025Article
- Review
- The multifunctionality of the brainstem breathing control circuit.Current opinion in neurobiology · 2025Review
- Polyvagal theory: a journey from physiological observation to neural innervation and clinical insight.Frontiers in behavioral neuroscience · 2025Article
- The road toward a physiological control of artificial respiration: the role of bio-inspired neuronal networks.Frontiers in neuroscience · 2025Article
- Proof of concept for high-dose Cannabidiol pretreatment to antagonize opioid induced persistent apnea in mice.Frontiers in neuroscience · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We assessed the mechanism of mammalian breathing rhythmogenesis in the preBötzinger complex (preBötC) in vitro, where experimental tests remain inconsistent with hypotheses of canonical rhythmogenic cellular or synaptic mechanisms, i.e., pacemaker neurons or inhibition. Under rhythmic conditions, in each cycle, an inspiratory burst emerges as (presumptive) preBötC rhythmogenic neurons transition from aperiodic uncorrelated population spike activity to become increasingly synchronized during preinspiration (for ∼50-500 ms), which can trigger inspiratory bursts that propagate to motoneurons. In nonrhythmic conditions, antagonizing GABA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.