Evidence map›Paper›PMID 32130790›Full record

ArticleCancer medicine2020

Density of breast: An independent risk factor for developing breast cancer, a prospective study at two premium breast centers.

Chia Hwee Lo, Xin Ying Chai, Shirley Shy Wen Ting, Sze Chao Ang, Xinlin Chin, Lay Teng Tan, Peeroo Saania, Tuan Nur' Azmah Tuan Mat, Seniyah Mat Sikin, Anil Gandhi

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chia Hwee LoJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Xin Ying ChaiJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Shirley Shy Wen TingJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Sze Chao AngJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Xinlin ChinJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Lay Teng TanJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Peeroo SaaniaJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.
Tuan Nur' Azmah Tuan MatDepartment of Surgery, Hospital Sultanah Aminah (HSA), Johor Bahru, Malaysia.
Seniyah Mat SikinDepartment of Surgery, Hospital Sultan Ismail (HSI), Johor Bahru, Malaysia.
Anil GandhiJeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Malaysia.ORCID 0000-0001-6721-5880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is the leading cause of death among women worldwide. Studies have identified breast density as a controversial risk factor of breast cancer. Moreover, studies found that breast density reduction through Tamoxifen could reduce risk of breast cancer significantly. To date, no study on the association between breast density and breast cancer has been carried out in Malaysia. If breast density is proven to be a risk factor of breast cancer, intervention could be carried out to reduce breast cancer risk through breast density reduction. PURPOSE: To determine if density of breast is an independent risk factor which will contribute to development of breast cancer. MATERIALS AND

methodsA prospective cohort study is carried out in two hospitals targeting adult female patients who presented to the Breast Clinic with symptoms suspicious of breast cancer. Participants recruited were investigated for breast cancer based on their symptoms. Breast density assessed from mammogram was correlated with tissue biopsy results and final diagnosis of benign or malignant breast disease.

resultsParticipants with dense breasts showed 29% increased risk of breast cancer when compared to those with almost entirely fatty breasts (odds ratio [OR] 1.29, 95% CI 0.38-4.44, P = .683). Among the postmenopausal women, those with dense breasts were 3.1 times more likely to develop breast cancer compared with those with fatty breasts (OR 3.125, 95% CI 0.72-13.64, P = .13). Moreover, the chance of developing breast cancer increases with age (OR 1.046, 95% CI 1.003-1.090, P < .05). In contrast, the density of breast decreases with increasing age (P < .05) and body mass index (P = .051). The proportion of high breast density whether in the whole sample size, premenopausal, or postmenopausal group was consistently high.

conclusionAlthough results were not statistically significant, important association between breast density and risk of breast cancer cannot be ruled out. The study is limited by a small sample size and subjective assessment of breast density. More studies are required to reconcile the differences between studies of contrasting evidence.

Indexed as

Breast DensityBreast NeoplasmsEarly Detection of CancerFemaleFollow-Up StudiesHumansMalaysiaMammographyMiddle AgedPrognosisProspective StudiesRisk AssessmentRisk FactorsBI-RADSbreast cancerbreast density

Identifiers

PMID32130790
PMCPMC7196055

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