Evidence map›Paper›PMID 32130650›Full record

ArticleObesity surgery2020

Long-Term Evaluation of Biliary Reflux on Esogastric Mucosae after One-Anastomosis Gastric Bypass and Esojejunostomy in Rats.

Leïla M'Harzi, Jean-Marc Chevallier, Anais Certain, Gwennhaël Autret, Guillaume Levenson, David Louis, Tigran Poghosyan, Arthur Berger, Gabriel Rahmi, Chloé Broudin and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Leïla M'HarziGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France.
Jean-Marc ChevallierGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France.
Anais CertainINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Gwennhaël AutretINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Guillaume LevensonGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France.
David LouisINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Tigran PoghosyanGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France.
Arthur BergerINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Gabriel RahmiINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Chloé BroudinINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Olivier ClémentINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Richard DouardGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France.
Bertrand TavitianINSERM 970, Équipe 2, PARCC, HEGP, Paris, France.
Matthieu BruzziGeneral and Digestive Surgery Unit, Georges Pompidou, AP-HP University Hospital, 20 Rue Leblanc, 75908, Paris Cedex 15, France. matthieu.bruzzi@aphp.fr.
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRParis Cardiovascular Research Center · FRHôpital Européen Georges-Pompidou · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne-anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) remains controversial because it may cause chronic biliary reflux (BR). The risk of developing esogastric cancer due to BR after OAGB/MGB is based on the results of experimental rat studies using esojejunostomy (EJ). The aim of this study was to analyze the potential long-term consequences of BR on the esogastric mucosae in OAGB/MGB-operated rats and to compare these results to those from the use of EJ.

methodsWistar rats received OAGB/MGB (n = 16), EJ (n = 16), and sham (n = 8) operations. Mortality and weight changes were evaluated throughout the experiment. BR was measured using magnetic resonance imaging (MRI). Rats received follow-ups for 30 weeks. A double-blinded histological analysis was performed in the esogastric segments.

resultsBR was diagnosed in OAGB/MGB and EJ rats using the MRI technique; no BR occurred in the sham group. After a 30-week follow-up, no incidences of dysplasia or cancer were observed in the three groups. Additionally, esophageal intestinal metaplasia and mucosal ulcerations were observed in 41.7% and 50% of EJ rats, respectively, and no incidences of these conditions were observed in OAGB/MGB and sham rats. The incidence of esophagitis was significantly higher and more severe in the EJ group compared to those in the OAGB/MGB and sham groups (EJ = 100%, OAGB/MGB = 16.7%, sham = 8.3%; p < 0.001).

conclusionsAfter a 30-week follow-up period, OAGB/MGB rats did not develop any precancerous or cancerous lesions when more than 40% of EJ rats had intestinal metaplasia.

Indexed as

Bile RefluxGastric BypassObesity, MorbidAnimalsRatsRats, WistarWeight LossBariatric surgeryBiliary refluxCancerMetaplasiaMini gastric bypassMorbid obesityOne anastomosis gastric bypass

Identifiers

PMID32130650
OpenAlexW3010348891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.