Evidence map›Paper›PMID 32130604›Full record

ArticleDoklady. Biochemistry and biophysics2019

Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes.

N V Maluchenko, D S Sultanov, E Yu Kotova, M P Kirpichnikov, V M Studitsky, A V Feofanov

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Mechanisms of Nucleosome Reorganization by PARP1.International journal of molecular sciences · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

N V MaluchenkoMoscow State University, 119234, Moscow, Russia. mal_nat@mail.ru.
D S SultanovFox Chase Cancer Center, Philadelphia, USA.
E Yu KotovaFox Chase Cancer Center, Philadelphia, USA.
M P KirpichnikovMoscow State University, 119234, Moscow, Russia.
V M StuditskyMoscow State University, 119234, Moscow, Russia.
A V FeofanovMoscow State University, 119234, Moscow, Russia.
Lomonosov Moscow State University · RUFox Chase Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

Indexed as

AnimalsHistonesNucleosomesPoly (ADP-Ribose) Polymerase-1Xenopus laevisHistonesNucleosomesPoly (ADP-Ribose) Polymerase-1

Identifiers

PMID32130604
OpenAlexW2995642053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.