Evidence map›Paper›PMID 32130549›Full record

ArticleNanoscale research letters2020

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging.

Yan Gao, Jian Kang, Zhen Lei, Yankun Li, Xifan Mei, Guannan Wang

Abstract read
In one paragraph

Article in Nanoscale research letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan GaoThe First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
Jian KangCollege of Pharmacy, Jinzhou Medical University, Jinzhou, 121001, China.
Zhen LeiThe First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China. leizhen2004@163.com.
Yankun LiThe First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China.
Xifan MeiThe First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, China. meixifan1971@163.com.
Guannan WangCollege of Pharmacy, Jinzhou Medical University, Jinzhou, 121001, China. chemwangguannan@gmail.com.ORCID http://orcid.org/0000-0003-3593-5589

Funding

LiaoNing Revitalization Talents Program XLYC1807037National Natural Science Foundation of China 81671742
6 · The paper itself

Abstract

In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au nanocages@PEG nanoparticles (AuNC@PEGs) with a strong X-ray absorption coefficient was synthesized as a contrast agent for computed tomography (CT) scan imaging. Results showed that AuNC@PEGs had good aqueous dispensation, low cytotoxicity, and strong X-ray absorption ability. Furthermore, in vivo studies have shown that the synthesized AuNC@PEGs have an evident contrast enhancement, long circulation time in the blood, and negligible toxicity in vivo. Therefore, the synthesized functionalized AuNC@PEGs in this study have great potential for clinical application in CT scan imaging.

Indexed as

AuNC@PEGsBiocompatibilityContrast agentIn vivo CT imaging

Identifiers

PMID32130549
PMCPMC7056796

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.